Fig. 1

Viability of patient derived fibroblasts and primary glioblastoma cells under the influence of carnosine. Fibroblast cell cultures (11) and primary GBM cell cultures (9) were exposed for 48 h to different concentrations of carnosine (0, 50 or 75 mM). Viability was determined by measuring the amount of ATP in cell lysates (a) and by assessing metabolic activity (b). Each dot within the boxplots represents the mean obtained from six measurements of an individual cell culture. For comparison, the grey-colored dots (depicted by arrows) indicate the results obtained from experiments with the cell line T98G which was used for co-culture experiments. Statistical significance using data obtained from 11 fibroblast cultures and 9 primary GBM cultures was determined using Student’s t-test with: *p < 0.05; **p < 0.005; ***p < 0.0005