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Fig. 4 | Cancer Cell International

Fig. 4

From: TAZ inhibition promotes IL-2-induced apoptosis of hepatocellular carcinoma cells by activating the JNK/F-actin/mitochondrial fission pathway

Fig. 4

TAZ regulates mitochondrial fission. a, b Immunofluorescence staining of mitochondria. The average number of mitochondria was recorded. IL-2 treatment significantly activated mitochondrial fission, and this effect was further enhanced by TAZ deletion. cf To quantify mitochondrial fission, the expression of mitochondrial fission-related proteins was analyzed. g Capsase-3 activity was measured in HepG2 cell transfected with TAZ siRNA in the presence of IL-2. To inhibit mitochondrial fission, Mdivi-1 was added to IL-2-treated cells. hi PI staining was used to observe apoptotic cells. *P < 0.05 vs. control (Ctrl) group; #P < 0.05 vs. IL-2 group; @P < 0.05 vs. IL-2 + si-TAZ group

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