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Fig. 5 | Cancer Cell International

Fig. 5

From: TAZ inhibition promotes IL-2-induced apoptosis of hepatocellular carcinoma cells by activating the JNK/F-actin/mitochondrial fission pathway

Fig. 5

TAZ-triggered mitochondrial fission causes mitochondrial dysfunction. a, b Cellular ROS production was measured by flow cytometry in HepG2 cell treated with TAZ siRNA in the presence of IL-2. Mdivi-1, an inhibitor of mitochondrial fission, was added to TAZ-depleted cells. ce Antioxidant concentrations were measured by ELISA. fg Immunofluorescence was used to analyze cyt-c leakage into the nucleus. h Caspase-9 activity was measured in response to TAZ deletion or mitochondrial fission inhibition. *P < 0.05 vs. control (Ctrl) group; #P < 0.05 vs. IL-2 group; @P < 0.05 vs. IL-2 + si-TAZ group

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