Fig. 7
The JNK/F-actin pathway is also involved in mitochondrial homeostasis. a, b JC-1 staining for mitochondrial membrane potential. Red fluorescence indicates normal mitochondria and green fluorescence indicates damaged mitochondria. c, d ROS production was evaluated via immunofluorescence. e Caspase-9 activity was measured to assess mitochondrial apoptosis. Inhibition of the JNK pathway abrogated the pro-apoptotic effects of TAZ on mitochondria in HepG2 cell. *P < 0.05 vs. control (Ctrl) group; #P < 0.05 vs. IL-2 group; @P < 0.05 vs. IL-2 + si-TAZ group