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Table 2 Gene ontology term enrichment of differentially expressed genes in the A549 and U87-MG SOX2OT knocked down cells

From: SOX2OT knockdown derived changes in mitotic regulatory gene network of cancer cells

A549 cell line

U87-MG cell line

GO-ID

p-value

Corr p-value

X

Description

GO-ID

p-value

Corr p-value

X

Description

9987

1.83E−05

9.26E−03

61

Cellular process

32502

4.68e−02

3.40e−01

96

Developmental process

44085

1.03E−04

1.06E−02

21

Cellular component biogenesis

6807

2.55e−03

3.19e−01

76

Nitrogen compound metabolic process

7049

6.16E−05

9.26E−03

17

Cell cycle

6950

2.55e−02

3.19e−01

58

Response to stress

22402

4.46E−04

1.90E−02

14

Cell cycle process

30154

4.98e−02

3.40e−01

53

Cell differentiation

48519

8.18E−05

9.85E−03

13

Negative regulation of biological process

42127

5.77e−03

3.19e−01

34

Regulation of cell proliferation

43933

2.12E−03

4.64E−02

13

Macromolecular complex subunit organization

6629

3.47e−02

3.40e−01

30

Lipid metabolic process

278

1.47E−04

1.18E−02

11

Mitotic cell cycle

6811

4.39e−02

3.40e−01

27

Ion transport

51301

5.24E−04

1.95E−02

11

Cell division

22008

2.10e−02

3.19e−01

25

Neurogenesis

22403

2.29E−03

4.73E−02

11

Cell cycle phase

48699

1.72e−02

3.19e−01

24

Generation of neurons

10605

3.55E−04

1.74E−02

10

Negative regulation of macromolecule metabolic process

8285

8.58e−03

3.19e−01

18

Negative regulation of cell proliferation

45892

6.13E−05

9.26E−03

9

Negative regulation of transcription, DNA-dependent

55086

2.43E−02

3.19E−01

14

Nucleobase, nucleoside and nucleotide metabolic process

45934

3.61E−04

1.74E−02

9

Negative regulation of nucleic acid metabolic process

6954

3.08e−02

3.40e−01

14

Inflammatory response

51172

3.61E−04

1.74E−02

9

Negative regulation of nitrogen compound metabolic process

7420

4.63e−02

3.40e−01

13

Brain development

6260

5.07E−04

1.95E−02

7

DNA replication

6916

3.19E−02

3.40E−01

10

Anti-apoptosis

9628

1.19E−03

3.18E−02

7

Response to abiotic stimulus

6260

4.82e−02

3.40e−01

9

DNA replication

6261

2.03E−03

4.59E−02

5

DNA-dependent DNA replication

1525

4.03E−02

3.40E−01

8

Angiogenesis

10688

2.93E−04

1.74E−02

2

Negative regulation of ribosomal protein gene transcription

51325

1.84e−02

3.19e−01

7

Interphase

30837

2.00E−03

4.59E−02

2

Negative regulation of actin filament polymerization

7265

2.41e−02

3.19e−01

7

Ras protein signal transduction

32272

2.00E−03

4.59E−02

2

Negative regulation of protein polymerization

82

4.27e−02

3.40e−01

4

G1/s transition of mitotic cell cycle

8154

2.00E−03

4.59E−02

2

Actin polymerization or depolymerization

48048

8.49e−03

3.19e−01

3

Embryonic eye morphogenesis

  1. X: the number of genes in enriched GO term, corr p-value: FDR corrected p-value