From: Sulbactam-enhanced cytotoxicity of doxorubicin in breast cancer cells
Protein name | Abbreviation | UniProt ID | Mass (Da) | pI | Spectrum count | Dox + Sul/Dox | p value | Biological process | |
---|---|---|---|---|---|---|---|---|---|
Dox | Dox + Sul | Folda | |||||||
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 | DHX15 | O43143 | 90,932.8 | 7.1 | 0.00 | 0.82 | 100.00 | 2.57E−07 | RNA processing |
U5 small nuclear ribonucleoprotein 200 kDa helicase | SNRNP200 | O75643 | 244,507.6 | 5.7 | 0.00 | 1.10 | 100.00 | 2.41E−02 | RNA processing |
Spliceosome RNA helicase DDX39B | DDX39B | Q5STU3 | 48,826.1 | 7.2 | 0.00 | 1.85 | 100.00 | 2.52E−05 | RNA processing |
ATP-dependent RNA helicase DDX3X | DDX3X | O00571 | 73,112.2 | 6.7 | 0.00 | 1.39 | 100.00 | 7.43E−04 | RNA processing |
Nucleolar protein 14 | NOP14 | P78316 | 97,668.7 | 9.1 | 0.00 | 0.96 | 100.00 | 1.50E−03 | RNA processing |
Growth arrest and DNA damage-inducible proteins-interacting protein 1 | GADD45GIP1 | Q8TAE8 | 25,383.9 | 9.5 | 0.00 | 1.09 | 100.00 | 2.70E−02 | Response to DNA damage |
26S protease regulatory subunit 6A | PSMC3 | P17980 | 49,203.5 | 5.1 | 0.27 | 1.11 | 4.06 | 4.64E−02 | Response to DNA damage |
Proteasome subunit beta type-4 | PSMB4 | P28070 | 29,204.3 | 9.1 | 0.00 | 0.96 | 100.00 | 1.08E−03 | Response to DNA damage |
Transformation/transcription domain-associated protein | TRRAP | Q9Y4A5 | 437,601.8 | 9.1 | 0.00 | 0.55 | 100.00 | 3.412E−05 | Response to DNA damage |
Protein DEK | DEK | P35659 | 42,674.4 | 9.3 | 0.00 | 1.53 | 100.00 | 6.37E−03 | Response to DNA damage |
Serine/threonine-protein kinase BRSK1 | BRSK1 | Q8TDC3 | 85,087.0 | 9.5 | 0.00 | 0.55 | 100.00 | 2.57E−07 | Response to DNA damage |
Adenomatous polyposis coli protein | APC | E7EMH9 | 32,790.8 | 5.4 | 0.00 | 0.55 | 100.00 | 3.41E−05 | Response to DNA damage |
Dihydropyrimidinase-related protein 2 | DPYSL2 | Q16555 | 62,293.6 | 5.9 | 0.00 | 0.98 | 100.00 | 1.32E−02 | Response to stress |
Sodium/potassium-transporting ATPase subunit beta-1 | ATP1B1 | P05026 | 35,061.3 | 9.1 | 0.00 | 1.11 | 100.00 | 7.81E−03 | Response to stress |
ERO1-like protein alpha | ERO1L | Q96HE7 | 51,991.8 | 5.4 | 0.00 | 0.56 | 100.00 | 1.12E−04 | Response to stress |
STE20-like serine/threonine-protein kinase | SLK | Q9H2G2 | 142,695.4 | 3.7 | 0.00 | 0.70 | 100.00 | 2.30E−02 | Response to stress |
Heat shock-related 70 kDa protein 2 | HSPA2 | P54652 | 70,021.0 | 5.6 | 0.00 | 2.69 | 100.00 | 9.41E−04 | Response to stress |
Putative heat shock 70 kDa protein 7 | HSPA6 | P48741 | 40,244.4 | 7.7 | 0.00 | 3.08 | 100.00 | 5.50E−03 | Response to stress |
Lipoprotein, Lp(A) | LPA | Q1HP67 | 226,516.1 | 7.2 | 0.00 | 0.55 | 100.00 | 2.57E−07 | Response to stress |
Apolipoprotein(a) | LPA | P08519 | 501,319.8 | 7.2 | 0.00 | 0.55 | 100.00 | 2.57E−07 | Response to stress |
Peroxiredoxin-6 | PRDX6 | P30041 | 24,903.8 | 6.0 | 0.27 | 1.68 | 6.15 | 1.42E−02 | Response to stress |
Solute carrier family 12 member 2 | SLC12A2 | P55011 | 131,447.1 | 6.0 | 0.37 | 2.21 | 6.03 | 4.53E−03 | Response to stress |
Thioredoxin-related transmembrane protein 1 | TMX1 | Q9H3N1 | 31,791.3 | 3.7 | 0.00 | 0.83 | 100.00 | 2.70E−04 | Response to stress |
Transmembrane protein 109 | TMEM109 | Q9BVC6 | 26,210.1 | 11.2 | 0.00 | 0.56 | 100.00 | 2.70E−04 | Response to stress |
MICOS complex subunit MIC60 | IMMT | Q16891 | 80,026.5 | 5.7 | 1.12 | 2.74 | 2.45 | 1.34E−04 | Response to stress |
Signal transducer and activator of transcription | STAT1 | J3KPM9 | 83,360.6 | 7.2 | 0.00 | 0.83 | 100.00 | 2.70E−04 | Response to stress |
cDNA FLJ78587 | TUBA1B | A8JZY9 | 50,135.7 | 5.4 | 4.80 | 14.97 | 3.12 | 5.22E−03 | Cytoskeleton organization |
Myosin regulatory light chain 12A | MYL12A | P19105 | 19,794.1 | 4.7 | 1.23 | 5.81 | 4.71 | 3.07E−02 | Cytoskeleton organization |
Myosin regulatory light chain 12B | MYL12B | O14950 | 19,779.2 | 4.7 | 1.23 | 5.81 | 4.71 | 3.07E−02 | Cytoskeleton organization |
Actin-like protein 8 | ACTL8 | Q9H568 | 41,360.4 | 7.2 | 0.27 | 1.11 | 4.06 | 4.64E−02 | Cytoskeleton organization |
Plastin-1 | PLS1 | Q14651 | 70,253.6 | 5.4 | 0.00 | 0.97 | 100.00 | 7.05E−03 | Cytoskeleton organization |
F-actin-capping protein subunit beta | CAPZB | P47756 | 31,219.3 | 5.4 | 0.00 | 2.46 | 100.00 | 4.59E−02 | Cytoskeleton organization |
Vimentin | VIM | B0YJC5 | 26,858.9 | 3.7 | 0.00 | 0.69 | 100.00 | 2.03E−02 | Cytoskeleton organization |
Filamin A | FLNA | Q60FE5 | 278,226.9 | 7.2 | 2.51 | 7.53 | 3.01 | 2.05E−02 | Cytoskeleton organization |
Tubulin-folding cofactor B | TBCB | Q99426 | 27,325.5 | 8.7 | 0.00 | 0.70 | 100.00 | 2.30E−02 | Cytoskeleton organization |
Tubulin beta-3 chain | TUBB3 | Q13509 | 50,432.7 | 4.8 | 1.41 | 6.70 | 4.75 | 3.23E−02 | Cytoskeleton organization |
Tubulin beta-4A chain | TUBB4A | P04350 | 49,585.8 | 4.8 | 0.00 | 1.94 | 100.00 | 2.70E−04 | Cytoskeleton organization |
Kinesin heavy chain isoform 5C | KIF5C | O60282 | 109,494.8 | 5.9 | 0.00 | 1.10 | 100.00 | 3.85E−02 | Cytoskeleton organization |
Septin-9 | SEPTIN9 | Q9UHD8 | 65,401.6 | 9.5 | 0.00 | 1.40 | 100.00 | 1.64E−02 | Cytoskeleton organization |
Laminin subunit alpha-2 | LAMA2 | A0A087WYF1 | 343,419.0 | 7.2 | 0.28 | 1.26 | 4.46 | 4.32E−02 | Cytoskeleton organization |
Malectin | MLEC | Q14165 | 32,233.9 | 7.2 | 0.00 | 0.70 | 100.00 | 2.15E−02 | Protein folding |
T-complex protein 1 subunit gamma | CCT3 | Q2TU64 | 60,579.1 | 7.2 | 0.00 | 3.62 | 100.00 | 1.49E−02 | Protein folding |
Vesicle-associated membrane protein-associated protein B/C | VAPB | E5RK64 | 7801.0 | 9.5 | 0.00 | 1.54 | 100.00 | 3.83E−02 | Protein folding |
PEST proteolytic signal-containing nuclear protein | PCNP | Q8WW12 | 18,924.9 | 6.9 | 0.28 | 1.91 | 6.95 | 2.46E−02 | Ubiquitin-dependent protein catabolic process |
NEDD8-conjugating enzyme Ubc12 | UBE2 M | P61081 | 20,900.0 | 9.1 | 0.00 | 0.83 | 100.00 | 2.70E−04 | Ubiquitin-dependent protein catabolic process |
Cullin-3 | CUL3 | A0A087WTG3 | 39,147.2 | 9.5 | 0.00 | 1.94 | 100.00 | 2.70E−04 | Ubiquitin-dependent protein catabolic process |
Coatomer subunit beta | COPB1 | P53618 | 107,142.6 | 7.2 | 0.00 | 1.10 | 100.00 | 3.02E−02 | Vesicle-mediated transport |
Endoplasmic reticulum resident protein 29 | ERP29 | F8VY02 | 18,115.9 | 9.1 | 0.00 | 0.55 | 100.00 | 3.41E−05 | Vesicle-mediated transport |
Kinesin-like protein KIF16B | KIF16B | Q96L93 | 152,011.7 | 7.2 | 0.00 | 1.12 | 100.00 | 3.33E−02 | Vesicle-mediated transport |
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A | PIGA | P37287 | 54,126.7 | 9.1 | 0 | 0.55 | 100.00 | 2.574E−07 | Vesicle-mediated transport |
Ras-related protein Rab-35 | RAB35 | Q15286 | 23,025.3 | 9.1 | 0.00 | 0.98 | 100.00 | 8.01E−03 | Vesicle-mediated transport |
Ras-related protein Rab-15 | RAB15 | P59190 | 24,390.6 | 5.5 | 0.00 | 0.98 | 100.00 | 8.01E−03 | Vesicle-mediated transport |
Ras-related protein Rab-15 isoform AN2 | RAB15 | G5ELZ5 | 13,781.8 | 9.1 | 0.00 | 0.98 | 100.00 | 8.01E−03 | Vesicle-mediated transport |
Ras-related protein Rab-15 isoform AN3 | RAB15 | G5ELZ6 | 12,759.7 | 9.1 | 0.00 | 0.98 | 100.00 | 8.01E−03 | Vesicle-mediated transport |
Enolase | ENO1 | F5H0C8 | 34,762.3 | 3.6 | 0.00 | 0.83 | 100.00 | 2.70E−04 | Carbohydrate metabolism |
Phosphoglycerate mutase | PGAM1 | A4D2J6 | 28,219.6 | 9.5 | 0.00 | 1.40 | 100.00 | 2.15E−02 | Carbohydrate metabolism |
ATP-dependent 6-phosphofructokinase, platelet type | PFKP | B1APP8 | 22,939.3 | 9.1 | 0.00 | 0.56 | 100.00 | 1.12E−04 | Carbohydrate metabolism |
Gamma-enolase | ENO2 | P09104 | 47,268.6 | 4.9 | 0.00 | 0.83 | 100.00 | 2.70E−04 | Carbohydrate metabolism |
Transaldolase | TALDO1 | F2Z393 | 35,328.9 | 9.5 | 0.00 | 2.75 | 100.00 | 3.85E−02 | Carbohydrate metabolism |
Ganglioside-induced differentiation-associated protein 1 | GDAP1 | Q8TB36 | 41,345.8 | 9.1 | 0.00 | 0.56 | 100.00 | 2.70E−04 | Amino acid metabolic process |
Multifunctional methyltransferase subunit TRM112-like protein | TRMT112 | F5GX77 | 11,972.0 | 7.8 | 0.00 | 0.56 | 100.00 | 1.12E−04 | Amino acid metabolic process |
GCSH protein | GCSH | Q6IAT2 | 19,025.8 | 3.7 | 0.00 | 0.96 | 100.00 | 8.84E−03 | Amino acid metabolic process |
Elongation factor 1-alpha 2 | EEF1A2 | Q05639 | 50,470.2 | 9.1 | 0.00 | 3.21 | 100.00 | 1.94E−02 | Positive regulation of apoptotic process |
Apoptotic chromatin condensation inducer in the nucleus | ACIN1 | Q9UKV3 | 151,861.9 | 5.4 | 0.00 | 0.82 | 100.00 | 1.30E−02 | Positive regulation of apoptotic process |