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Table 3 List of upregulated proteins in the Dox- and Sul-treated MDA-MB-468 cells

From: Sulbactam-enhanced cytotoxicity of doxorubicin in breast cancer cells

Protein name Abbreviation UniProt ID Mass (Da) pI Spectrum count Dox + Sul/Dox p value Biological process
Dox Dox + Sul Folda
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 DHX15 O43143 90,932.8 7.1 0.00 0.82 100.00 2.57E−07 RNA processing
U5 small nuclear ribonucleoprotein 200 kDa helicase SNRNP200 O75643 244,507.6 5.7 0.00 1.10 100.00 2.41E−02 RNA processing
Spliceosome RNA helicase DDX39B DDX39B Q5STU3 48,826.1 7.2 0.00 1.85 100.00 2.52E−05 RNA processing
ATP-dependent RNA helicase DDX3X DDX3X O00571 73,112.2 6.7 0.00 1.39 100.00 7.43E−04 RNA processing
Nucleolar protein 14 NOP14 P78316 97,668.7 9.1 0.00 0.96 100.00 1.50E−03 RNA processing
Growth arrest and DNA damage-inducible proteins-interacting protein 1 GADD45GIP1 Q8TAE8 25,383.9 9.5 0.00 1.09 100.00 2.70E−02 Response to DNA damage
26S protease regulatory subunit 6A PSMC3 P17980 49,203.5 5.1 0.27 1.11 4.06 4.64E−02 Response to DNA damage
Proteasome subunit beta type-4 PSMB4 P28070 29,204.3 9.1 0.00 0.96 100.00 1.08E−03 Response to DNA damage
Transformation/transcription domain-associated protein TRRAP Q9Y4A5 437,601.8 9.1 0.00 0.55 100.00 3.412E−05 Response to DNA damage
Protein DEK DEK P35659 42,674.4 9.3 0.00 1.53 100.00 6.37E−03 Response to DNA damage
Serine/threonine-protein kinase BRSK1 BRSK1 Q8TDC3 85,087.0 9.5 0.00 0.55 100.00 2.57E−07 Response to DNA damage
Adenomatous polyposis coli protein APC E7EMH9 32,790.8 5.4 0.00 0.55 100.00 3.41E−05 Response to DNA damage
Dihydropyrimidinase-related protein 2 DPYSL2 Q16555 62,293.6 5.9 0.00 0.98 100.00 1.32E−02 Response to stress
Sodium/potassium-transporting ATPase subunit beta-1 ATP1B1 P05026 35,061.3 9.1 0.00 1.11 100.00 7.81E−03 Response to stress
ERO1-like protein alpha ERO1L Q96HE7 51,991.8 5.4 0.00 0.56 100.00 1.12E−04 Response to stress
STE20-like serine/threonine-protein kinase SLK Q9H2G2 142,695.4 3.7 0.00 0.70 100.00 2.30E−02 Response to stress
Heat shock-related 70 kDa protein 2 HSPA2 P54652 70,021.0 5.6 0.00 2.69 100.00 9.41E−04 Response to stress
Putative heat shock 70 kDa protein 7 HSPA6 P48741 40,244.4 7.7 0.00 3.08 100.00 5.50E−03 Response to stress
Lipoprotein, Lp(A) LPA Q1HP67 226,516.1 7.2 0.00 0.55 100.00 2.57E−07 Response to stress
Apolipoprotein(a) LPA P08519 501,319.8 7.2 0.00 0.55 100.00 2.57E−07 Response to stress
Peroxiredoxin-6 PRDX6 P30041 24,903.8 6.0 0.27 1.68 6.15 1.42E−02 Response to stress
Solute carrier family 12 member 2 SLC12A2 P55011 131,447.1 6.0 0.37 2.21 6.03 4.53E−03 Response to stress
Thioredoxin-related transmembrane protein 1 TMX1 Q9H3N1 31,791.3 3.7 0.00 0.83 100.00 2.70E−04 Response to stress
Transmembrane protein 109 TMEM109 Q9BVC6 26,210.1 11.2 0.00 0.56 100.00 2.70E−04 Response to stress
MICOS complex subunit MIC60 IMMT Q16891 80,026.5 5.7 1.12 2.74 2.45 1.34E−04 Response to stress
Signal transducer and activator of transcription STAT1 J3KPM9 83,360.6 7.2 0.00 0.83 100.00 2.70E−04 Response to stress
cDNA FLJ78587 TUBA1B A8JZY9 50,135.7 5.4 4.80 14.97 3.12 5.22E−03 Cytoskeleton organization
Myosin regulatory light chain 12A MYL12A P19105 19,794.1 4.7 1.23 5.81 4.71 3.07E−02 Cytoskeleton organization
Myosin regulatory light chain 12B MYL12B O14950 19,779.2 4.7 1.23 5.81 4.71 3.07E−02 Cytoskeleton organization
Actin-like protein 8 ACTL8 Q9H568 41,360.4 7.2 0.27 1.11 4.06 4.64E−02 Cytoskeleton organization
Plastin-1 PLS1 Q14651 70,253.6 5.4 0.00 0.97 100.00 7.05E−03 Cytoskeleton organization
F-actin-capping protein subunit beta CAPZB P47756 31,219.3 5.4 0.00 2.46 100.00 4.59E−02 Cytoskeleton organization
Vimentin VIM B0YJC5 26,858.9 3.7 0.00 0.69 100.00 2.03E−02 Cytoskeleton organization
Filamin A FLNA Q60FE5 278,226.9 7.2 2.51 7.53 3.01 2.05E−02 Cytoskeleton organization
Tubulin-folding cofactor B TBCB Q99426 27,325.5 8.7 0.00 0.70 100.00 2.30E−02 Cytoskeleton organization
Tubulin beta-3 chain TUBB3 Q13509 50,432.7 4.8 1.41 6.70 4.75 3.23E−02 Cytoskeleton organization
Tubulin beta-4A chain TUBB4A P04350 49,585.8 4.8 0.00 1.94 100.00 2.70E−04 Cytoskeleton organization
Kinesin heavy chain isoform 5C KIF5C O60282 109,494.8 5.9 0.00 1.10 100.00 3.85E−02 Cytoskeleton organization
Septin-9 SEPTIN9 Q9UHD8 65,401.6 9.5 0.00 1.40 100.00 1.64E−02 Cytoskeleton organization
Laminin subunit alpha-2 LAMA2 A0A087WYF1 343,419.0 7.2 0.28 1.26 4.46 4.32E−02 Cytoskeleton organization
Malectin MLEC Q14165 32,233.9 7.2 0.00 0.70 100.00 2.15E−02 Protein folding
T-complex protein 1 subunit gamma CCT3 Q2TU64 60,579.1 7.2 0.00 3.62 100.00 1.49E−02 Protein folding
Vesicle-associated membrane protein-associated protein B/C VAPB E5RK64 7801.0 9.5 0.00 1.54 100.00 3.83E−02 Protein folding
PEST proteolytic signal-containing nuclear protein PCNP Q8WW12 18,924.9 6.9 0.28 1.91 6.95 2.46E−02 Ubiquitin-dependent protein catabolic process
NEDD8-conjugating enzyme Ubc12 UBE2 M P61081 20,900.0 9.1 0.00 0.83 100.00 2.70E−04 Ubiquitin-dependent protein catabolic process
Cullin-3 CUL3 A0A087WTG3 39,147.2 9.5 0.00 1.94 100.00 2.70E−04 Ubiquitin-dependent protein catabolic process
Coatomer subunit beta COPB1 P53618 107,142.6 7.2 0.00 1.10 100.00 3.02E−02 Vesicle-mediated transport
Endoplasmic reticulum resident protein 29 ERP29 F8VY02 18,115.9 9.1 0.00 0.55 100.00 3.41E−05 Vesicle-mediated transport
Kinesin-like protein KIF16B KIF16B Q96L93 152,011.7 7.2 0.00 1.12 100.00 3.33E−02 Vesicle-mediated transport
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A PIGA P37287 54,126.7 9.1 0 0.55 100.00 2.574E−07 Vesicle-mediated transport
Ras-related protein Rab-35 RAB35 Q15286 23,025.3 9.1 0.00 0.98 100.00 8.01E−03 Vesicle-mediated transport
Ras-related protein Rab-15 RAB15 P59190 24,390.6 5.5 0.00 0.98 100.00 8.01E−03 Vesicle-mediated transport
Ras-related protein Rab-15 isoform AN2 RAB15 G5ELZ5 13,781.8 9.1 0.00 0.98 100.00 8.01E−03 Vesicle-mediated transport
Ras-related protein Rab-15 isoform AN3 RAB15 G5ELZ6 12,759.7 9.1 0.00 0.98 100.00 8.01E−03 Vesicle-mediated transport
Enolase ENO1 F5H0C8 34,762.3 3.6 0.00 0.83 100.00 2.70E−04 Carbohydrate metabolism
Phosphoglycerate mutase PGAM1 A4D2J6 28,219.6 9.5 0.00 1.40 100.00 2.15E−02 Carbohydrate metabolism
ATP-dependent 6-phosphofructokinase, platelet type PFKP B1APP8 22,939.3 9.1 0.00 0.56 100.00 1.12E−04 Carbohydrate metabolism
Gamma-enolase ENO2 P09104 47,268.6 4.9 0.00 0.83 100.00 2.70E−04 Carbohydrate metabolism
Transaldolase TALDO1 F2Z393 35,328.9 9.5 0.00 2.75 100.00 3.85E−02 Carbohydrate metabolism
Ganglioside-induced differentiation-associated protein 1 GDAP1 Q8TB36 41,345.8 9.1 0.00 0.56 100.00 2.70E−04 Amino acid metabolic process
Multifunctional methyltransferase subunit TRM112-like protein TRMT112 F5GX77 11,972.0 7.8 0.00 0.56 100.00 1.12E−04 Amino acid metabolic process
GCSH protein GCSH Q6IAT2 19,025.8 3.7 0.00 0.96 100.00 8.84E−03 Amino acid metabolic process
Elongation factor 1-alpha 2 EEF1A2 Q05639 50,470.2 9.1 0.00 3.21 100.00 1.94E−02 Positive regulation of apoptotic process
Apoptotic chromatin condensation inducer in the nucleus ACIN1 Q9UKV3 151,861.9 5.4 0.00 0.82 100.00 1.30E−02 Positive regulation of apoptotic process
  1. Sul sulbactam, Dox doxorubicin
  2. aThe fold is from Dox + Sul/Dox, if the number of Dox is 0.00, the fold would be shown as 100.00