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Table 3 List of upregulated proteins in the Dox- and Sul-treated MDA-MB-468 cells

From: Sulbactam-enhanced cytotoxicity of doxorubicin in breast cancer cells

Protein name

Abbreviation

UniProt ID

Mass (Da)

pI

Spectrum count

Dox + Sul/Dox

p value

Biological process

Dox

Dox + Sul

Folda

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15

DHX15

O43143

90,932.8

7.1

0.00

0.82

100.00

2.57E−07

RNA processing

U5 small nuclear ribonucleoprotein 200 kDa helicase

SNRNP200

O75643

244,507.6

5.7

0.00

1.10

100.00

2.41E−02

RNA processing

Spliceosome RNA helicase DDX39B

DDX39B

Q5STU3

48,826.1

7.2

0.00

1.85

100.00

2.52E−05

RNA processing

ATP-dependent RNA helicase DDX3X

DDX3X

O00571

73,112.2

6.7

0.00

1.39

100.00

7.43E−04

RNA processing

Nucleolar protein 14

NOP14

P78316

97,668.7

9.1

0.00

0.96

100.00

1.50E−03

RNA processing

Growth arrest and DNA damage-inducible proteins-interacting protein 1

GADD45GIP1

Q8TAE8

25,383.9

9.5

0.00

1.09

100.00

2.70E−02

Response to DNA damage

26S protease regulatory subunit 6A

PSMC3

P17980

49,203.5

5.1

0.27

1.11

4.06

4.64E−02

Response to DNA damage

Proteasome subunit beta type-4

PSMB4

P28070

29,204.3

9.1

0.00

0.96

100.00

1.08E−03

Response to DNA damage

Transformation/transcription domain-associated protein

TRRAP

Q9Y4A5

437,601.8

9.1

0.00

0.55

100.00

3.412E−05

Response to DNA damage

Protein DEK

DEK

P35659

42,674.4

9.3

0.00

1.53

100.00

6.37E−03

Response to DNA damage

Serine/threonine-protein kinase BRSK1

BRSK1

Q8TDC3

85,087.0

9.5

0.00

0.55

100.00

2.57E−07

Response to DNA damage

Adenomatous polyposis coli protein

APC

E7EMH9

32,790.8

5.4

0.00

0.55

100.00

3.41E−05

Response to DNA damage

Dihydropyrimidinase-related protein 2

DPYSL2

Q16555

62,293.6

5.9

0.00

0.98

100.00

1.32E−02

Response to stress

Sodium/potassium-transporting ATPase subunit beta-1

ATP1B1

P05026

35,061.3

9.1

0.00

1.11

100.00

7.81E−03

Response to stress

ERO1-like protein alpha

ERO1L

Q96HE7

51,991.8

5.4

0.00

0.56

100.00

1.12E−04

Response to stress

STE20-like serine/threonine-protein kinase

SLK

Q9H2G2

142,695.4

3.7

0.00

0.70

100.00

2.30E−02

Response to stress

Heat shock-related 70 kDa protein 2

HSPA2

P54652

70,021.0

5.6

0.00

2.69

100.00

9.41E−04

Response to stress

Putative heat shock 70 kDa protein 7

HSPA6

P48741

40,244.4

7.7

0.00

3.08

100.00

5.50E−03

Response to stress

Lipoprotein, Lp(A)

LPA

Q1HP67

226,516.1

7.2

0.00

0.55

100.00

2.57E−07

Response to stress

Apolipoprotein(a)

LPA

P08519

501,319.8

7.2

0.00

0.55

100.00

2.57E−07

Response to stress

Peroxiredoxin-6

PRDX6

P30041

24,903.8

6.0

0.27

1.68

6.15

1.42E−02

Response to stress

Solute carrier family 12 member 2

SLC12A2

P55011

131,447.1

6.0

0.37

2.21

6.03

4.53E−03

Response to stress

Thioredoxin-related transmembrane protein 1

TMX1

Q9H3N1

31,791.3

3.7

0.00

0.83

100.00

2.70E−04

Response to stress

Transmembrane protein 109

TMEM109

Q9BVC6

26,210.1

11.2

0.00

0.56

100.00

2.70E−04

Response to stress

MICOS complex subunit MIC60

IMMT

Q16891

80,026.5

5.7

1.12

2.74

2.45

1.34E−04

Response to stress

Signal transducer and activator of transcription

STAT1

J3KPM9

83,360.6

7.2

0.00

0.83

100.00

2.70E−04

Response to stress

cDNA FLJ78587

TUBA1B

A8JZY9

50,135.7

5.4

4.80

14.97

3.12

5.22E−03

Cytoskeleton organization

Myosin regulatory light chain 12A

MYL12A

P19105

19,794.1

4.7

1.23

5.81

4.71

3.07E−02

Cytoskeleton organization

Myosin regulatory light chain 12B

MYL12B

O14950

19,779.2

4.7

1.23

5.81

4.71

3.07E−02

Cytoskeleton organization

Actin-like protein 8

ACTL8

Q9H568

41,360.4

7.2

0.27

1.11

4.06

4.64E−02

Cytoskeleton organization

Plastin-1

PLS1

Q14651

70,253.6

5.4

0.00

0.97

100.00

7.05E−03

Cytoskeleton organization

F-actin-capping protein subunit beta

CAPZB

P47756

31,219.3

5.4

0.00

2.46

100.00

4.59E−02

Cytoskeleton organization

Vimentin

VIM

B0YJC5

26,858.9

3.7

0.00

0.69

100.00

2.03E−02

Cytoskeleton organization

Filamin A

FLNA

Q60FE5

278,226.9

7.2

2.51

7.53

3.01

2.05E−02

Cytoskeleton organization

Tubulin-folding cofactor B

TBCB

Q99426

27,325.5

8.7

0.00

0.70

100.00

2.30E−02

Cytoskeleton organization

Tubulin beta-3 chain

TUBB3

Q13509

50,432.7

4.8

1.41

6.70

4.75

3.23E−02

Cytoskeleton organization

Tubulin beta-4A chain

TUBB4A

P04350

49,585.8

4.8

0.00

1.94

100.00

2.70E−04

Cytoskeleton organization

Kinesin heavy chain isoform 5C

KIF5C

O60282

109,494.8

5.9

0.00

1.10

100.00

3.85E−02

Cytoskeleton organization

Septin-9

SEPTIN9

Q9UHD8

65,401.6

9.5

0.00

1.40

100.00

1.64E−02

Cytoskeleton organization

Laminin subunit alpha-2

LAMA2

A0A087WYF1

343,419.0

7.2

0.28

1.26

4.46

4.32E−02

Cytoskeleton organization

Malectin

MLEC

Q14165

32,233.9

7.2

0.00

0.70

100.00

2.15E−02

Protein folding

T-complex protein 1 subunit gamma

CCT3

Q2TU64

60,579.1

7.2

0.00

3.62

100.00

1.49E−02

Protein folding

Vesicle-associated membrane protein-associated protein B/C

VAPB

E5RK64

7801.0

9.5

0.00

1.54

100.00

3.83E−02

Protein folding

PEST proteolytic signal-containing nuclear protein

PCNP

Q8WW12

18,924.9

6.9

0.28

1.91

6.95

2.46E−02

Ubiquitin-dependent protein catabolic process

NEDD8-conjugating enzyme Ubc12

UBE2 M

P61081

20,900.0

9.1

0.00

0.83

100.00

2.70E−04

Ubiquitin-dependent protein catabolic process

Cullin-3

CUL3

A0A087WTG3

39,147.2

9.5

0.00

1.94

100.00

2.70E−04

Ubiquitin-dependent protein catabolic process

Coatomer subunit beta

COPB1

P53618

107,142.6

7.2

0.00

1.10

100.00

3.02E−02

Vesicle-mediated transport

Endoplasmic reticulum resident protein 29

ERP29

F8VY02

18,115.9

9.1

0.00

0.55

100.00

3.41E−05

Vesicle-mediated transport

Kinesin-like protein KIF16B

KIF16B

Q96L93

152,011.7

7.2

0.00

1.12

100.00

3.33E−02

Vesicle-mediated transport

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

PIGA

P37287

54,126.7

9.1

0

0.55

100.00

2.574E−07

Vesicle-mediated transport

Ras-related protein Rab-35

RAB35

Q15286

23,025.3

9.1

0.00

0.98

100.00

8.01E−03

Vesicle-mediated transport

Ras-related protein Rab-15

RAB15

P59190

24,390.6

5.5

0.00

0.98

100.00

8.01E−03

Vesicle-mediated transport

Ras-related protein Rab-15 isoform AN2

RAB15

G5ELZ5

13,781.8

9.1

0.00

0.98

100.00

8.01E−03

Vesicle-mediated transport

Ras-related protein Rab-15 isoform AN3

RAB15

G5ELZ6

12,759.7

9.1

0.00

0.98

100.00

8.01E−03

Vesicle-mediated transport

Enolase

ENO1

F5H0C8

34,762.3

3.6

0.00

0.83

100.00

2.70E−04

Carbohydrate metabolism

Phosphoglycerate mutase

PGAM1

A4D2J6

28,219.6

9.5

0.00

1.40

100.00

2.15E−02

Carbohydrate metabolism

ATP-dependent 6-phosphofructokinase, platelet type

PFKP

B1APP8

22,939.3

9.1

0.00

0.56

100.00

1.12E−04

Carbohydrate metabolism

Gamma-enolase

ENO2

P09104

47,268.6

4.9

0.00

0.83

100.00

2.70E−04

Carbohydrate metabolism

Transaldolase

TALDO1

F2Z393

35,328.9

9.5

0.00

2.75

100.00

3.85E−02

Carbohydrate metabolism

Ganglioside-induced differentiation-associated protein 1

GDAP1

Q8TB36

41,345.8

9.1

0.00

0.56

100.00

2.70E−04

Amino acid metabolic process

Multifunctional methyltransferase subunit TRM112-like protein

TRMT112

F5GX77

11,972.0

7.8

0.00

0.56

100.00

1.12E−04

Amino acid metabolic process

GCSH protein

GCSH

Q6IAT2

19,025.8

3.7

0.00

0.96

100.00

8.84E−03

Amino acid metabolic process

Elongation factor 1-alpha 2

EEF1A2

Q05639

50,470.2

9.1

0.00

3.21

100.00

1.94E−02

Positive regulation of apoptotic process

Apoptotic chromatin condensation inducer in the nucleus

ACIN1

Q9UKV3

151,861.9

5.4

0.00

0.82

100.00

1.30E−02

Positive regulation of apoptotic process

  1. Sul sulbactam, Dox doxorubicin
  2. aThe fold is from Dox + Sul/Dox, if the number of Dox is 0.00, the fold would be shown as 100.00