Skip to main content

Table 4 List of downregulated proteins in the Dox- and Sul-treated MDA-MB-468 cells

From: Sulbactam-enhanced cytotoxicity of doxorubicin in breast cancer cells

Protein name Abbreviation UniProt ID Mass (Da) pI Spectrum count Dox + sul/Dox p value Biological process
Dox Dox + Sul Folda
60S ribosomal protein L4 RPL4 P36578 47,566.1 11.1 4.53 1.96 − 2.31 2.25E−02 Translation
60S ribosomal protein L17 RPL17 J3QLC8 20,246.8 9.5 1.84 0.27 − 6.76 4.24E−02 Translation
60S ribosomal protein L24 RPL24 C9JXB8 14,368.8 11.3 0.56 0.00 − 100.00 1.30E−04 Translation
60S ribosomal protein L27a RPL27A P46776 16,430.2 11.0 3.20 1.47 − 2.17 1.42E−02 Translation
60S ribosomal protein L37a RPL37A P61513 10,275.3 9.5 1.39 0.00 − 100.00 4.08E−03 Translation
40S ribosomal protein S3a RPS3A D6RAT0 25,887.1 9.5 7.51 0.00 − 100.00 4.01E−03 Translation
Eukaryotic translation initiation factor 1A, Y-chromosomal EIF1AY O14602 16,442.4 4.6 0.65 0.00 − 100.00 1.43E−03 Translation
Eukaryotic translation initiation factor 1A, X-chromosomal EIF1AX P47813 16,460.4 4.6 0.65 0.00 − 100.00 1.43E−03 Translation
Eukaryotic translation initiation factor 4 gamma 1 EIF4G1 B2RU10 176,207.3 5.4 1.12 0.00 − 100.00 3.18E−02 Translation
Eukaryotic translation initiation factor 3 subunit J EIF3 J O75822 29,062.4 3.7 1.38 0.27 − 5.10 1.16E−02 Translation
Eukaryotic translation initiation factor 6 EIF6 P56537 26,599.2 3.7 0.70 0.00 − 100.00 2.17E−02 Translation
Nascent polypeptide-associated complex subunit alpha NANA2 Q13765 23,383.9 4.5 1.57 0.00 − 100.00 1.47E−03 Translation
Nascent polypeptide-associated complex subunit alpha, muscle-specific form NANA F8VZJ2 15,016.0 4.9 1.57 0.00 − 100.00 1.47E−03 Translation
Eukaryotic translation elongation factor 1 beta 2 EEF1B2 A4D1M6 24,891.0 3.7 1.26 0.00 − 100.00 7.44E−03 Translation
Heterogeneous nuclear ribonucleoprotein D0 HNRNPD Q14103 38,434.2 7.6 4.25 2.39 − 1.78 2.07E−02 Translation
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 E9PMF1 12,586.3 9.5 0.84 0.00 − 100.00 8.80E−07 Translation
Heterogeneous nuclear ribonucleoproteins C1/C2 HNPNPC G3V2Q1 33,570.9 5.0 3.50 0.81 − 4.30 2.30E−02 Translation
KH domain-containing, RNA-binding, signal transduction-associated protein 1 KHDRBS1 Q07666 48,227.3 8.7 0.97 0.00 − 100.00 1.21E−02 Regulation of transcription
High mobility group protein HMG-I/HMG-Y HMGA1 P17096 11,544.8 10.3 1.53 0.70 − 2.19 2.87E−02 Regulation of transcription
cDNA FLJ54188, moderately similar to High mobility group protein HMG-I/HMG-Y HMGA1 B4DWA0 34,301.4 10.4 1.53 0.70 − 2.19 2.87E−02 Regulation of transcription
Serrate RNA effector molecule homolog SRRT Q9BXP5 100,666.7 7.2 0.97 0.00 − 100.00 7.88E−03 Regulation of transcription
Protein SIX6OS1 C14orf39 Q8N1H7 68,166.0 5.4 0.56 0.00 − 100.00 1.30E−04 Regulation of transcription
Heterogeneous nuclear ribonucleoprotein D-like HNRPDL O14979 46,437.5 9.6 2.23 0.00 − 100.00 9.63E−03 Regulation of transcription
Zinc finger and BTB domain-containing protein 14 ZFP161 O43829 50,956.5 5.4 0.74 0.00 − 100.00 9.26E−03 Regulation of transcription
Golgin-45 BLZF1 Q9H2G9 44,910.4 9.1 0.70 0.00 − 100.00 1.68E−02 Regulation of transcription
Zinc finger protein neuro-d4 DPF1 E9PDV3 45,285.6 7.2 0.56 0.00 − 100.00 1.30E−04 Regulation of transcription
Histone cluster 1, H1e HIST1H1E Q4VB24 21,893.3 9.5 4.44 0.00 − 100.00 1.25E−02 Regulation of transcription
Serine/arginine-rich splicing factor 10 SRSF10 O75494 31,300.5 11.2 0.56 0.00 − 100.00 1.30E−04 RNA processing
Heterogeneous nuclear ribonucleoprotein Q SYNCRIP O60506 69,471.4 8.7 5.98 1.95 − 3.07 3.52E−02 RNA processing
Transformer-2 protein homolog alpha TRA2A Q13595 32,688.6 11.2 1.11 0.18 − 6.02 3.23E−02 RNA processing
Multidrug resistance protein 1 ABCB1 P08183 141,479.1 9.1 3.47 0.84 − 4.13 5.08E−04 Transporters
ATP-binding cassette sub-family G member 2 ABCG2 Q9UNQ0 72,314.0 8.9 1.66 0.36 − 4.56 1.05E−03 Transporters
ATP-binding cassette sub-family A member 8 ABCA8 O94911 179,245.9 9.1 0.56 0.00 − 100.00 8.80E−07 Transporters
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 E9PRA5 57,244.4 9.1 0.56 0.00 − 100.00 1.30E−04 Transporters
Syntaxin-8 STX8 Q9UNK0 26,906.8 3.7 0.56 0.00 − 100.00 8.80E−07 Transporters
Wiskott-Aldrich syndrome protein family member 1 WASF1 Q92558 61,652.4 5.4 0.56 0.00 − 100.00 1.30E−04 Cytoskeleton organization
Actin-related protein 2/3 complex subunit 2 ARPC2 O15144 34,333.1 9.1 1.23 0.00 − 100.00 5.68E−03 Cytoskeleton organization
Actin-related protein 2/3 complex subunit 3 ARPC3 O15145 20,415.5 8.8 0.97 0.00 − 100.00 7.88E−03 Cytoskeleton organization
Ras GTPase-activating-like protein IQGAP1 IQGAP1 P46940 189,120.8 6.1 1.25 0.00 − 100.00 4.32E−04 Cytoskeleton organization
Myosin light chain 6B MYL6B P14649 22764.1 6.3 2.23 0.00 − 100.00 8.80E−07 Cytoskeleton organization
TBC1 domain family member 31 WDR67 Q96DN5 124189.8 9.1 1.11 0.00 − 100.00 9.75E−04 Cytoskeleton organization
Prelamin-A/C LMNA Q5TCI8 55762.4 6.6 10.73 0.28 − 37.73 1.74E−02 Cytoskeleton organization
Lamin A/C LMNA W8QEH3 65116.9 9.1 11.69 0.00 − 100.00 8.86E−03 Cytoskeleton organization
Calumenin CALU O43852 34961.1 4.5 1.66 0.36 − 4.60 2.73E−02 Cytoskeleton organization
Lamina-associated polypeptide 2, isoforms beta/gamma TMPO P42167 50670.3 9.5 1.85 0.74 − 2.49 2.75E−02 Cytoskeleton organization
Kinesin-like protein KIF15 A0A087X0P0 312105.2 5.5 2.19 0.00 − 100.00 6.76E−06 Cytoskeleton organization
DnaJ homolog subfamily A member 1 DNAJA1 P31689 44868.4 7.2 1.26 0.36 − 3.44 2.12E−02 Protein folding
T-complex protein 1 subunit epsilon CCT5 P48643 59539.8 5.4 3.47 0.41 − 8.39 9.26E−03 Protein folding
T-complex protein 1 subunit beta CCT2 P78371 57357.0 6.0 1.11 0.00 − 100.00 1.30E−04 Protein folding
Cysteine and histidine-rich domain-containing protein 1 CHORDC1 Q9UHD1 37489.9 7.2 0.55 0.00 − 100.00 6.76E−06 Protein folding
CDC37 protein CDC37 Q6FG59 44453.5 3.7 1.78 0.41 − 4.38 4.29E−02 Protein folding
26S proteasome non-ATPase regulatory subunit 7 PSMD7 P51665 37025.4 6.3 0.69 0.00 − 100.00 1.95E−02 Protein catabolic process
Proteasome subunit beta type-3 PSMB3 P49720 22949.0 9.1 0.56 0.00 − 100.00 1.30E−04 Protein catabolic process
Proteasome subunit alpha type-4 PSMA4 P25789 29483.8 7.6 0.65 0.00 − 100.00 1.01E−03 Protein catabolic process
Ubiquitin carboxyl-terminal hydrolase 43 USP43 Q70EL4 122809.5 9.5 0.83 0.00 − 100.00 4.42E−02 Protein catabolic process
Enolase-like protein ENO4 ENO4 J3KNX1 68464.9 6.3 1.11 0.00 − 100.00 5.54E−03 Carbohydrate metabolism
PCK2 protein PCK2 Q6IB91 70697.2 7.2 0.70 0.00 − 100.00 2.17E−02 Carbohydrate metabolism
Fructose-bisphosphate aldolase ALDOC A8MVZ9 36295.3 7.6 1.53 0.00 − 100.00 2.78E−03 Carbohydrate metabolism
Cytochrome c oxidase subunit 5A, mitochondrial COX5A H3BNX8 17234.9 7.2 1.24 0.00 − 100.00 4.42E−02 Mitochondrial metabolic process
Cytochrome b5 type B CYB5B J3KNF8 16694.6 6.3 0.82 0.00 − 100.00 4.69E−02 Mitochondrial metabolic process
Cytochrome b-c1 complex subunit 1, mitochondrial UQCRC1 P31930 52646.0 7.2 0.56 0.00 − 100.00 1.30E−04 Mitochondrial metabolic process
MICOS complex subunit MIC19 CHCHD3 Q9NX63 26152.4 9.1 0.70 0.00 − 100.00 1.68E−02 Mitochondrial metabolic process
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial PCK2 Q16822 70730.2 7.2 0.70 0.00 − 100.00 2.17E−02 Mitochondrial metabolic process
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial DLST P36957 48755.5 9.5 0.56 0.00 − 100.00 1.30E−04 Mitochondrial metabolic process
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial PDHA1 P08559 43295.8 9.1 0.56 0.00 − 100.00 1.30E−04 Mitochondrial metabolic process
Apoptosis inhibitor 5 API5 Q9BZZ5 59004.7 9.1 1.21 0.27 − 4.44 4.79E−02 Negative regulation of apoptotic process
Epidermal growth factor receptor EGFR A9CB80 132022.7 6.2 6.03 0.54 − 11.12 5.65E−03 Signal transduction
A-kinase anchor protein 9 AKAP9 Q99996 453668.7 3.7 0.84 0.00 − 100.00 7.75E−05 Signal transduction
Rho GDP-dissociation inhibitor 1 ARHGDIA J3KS60 9944.0 4.2 0.65 0.00 − 100.00 5.33E−03 Signal transduction
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit PPP1CA P62136 37512.2 7.2 1.81 0.00 − 100.00 4.26E−03 Signal transduction
  1. Sul sulbactam, Dox doxorubicin
  2. aThe fold is from Dox/Dox + Sul, and “−” means the expression of protein was decrease in Dox + Sul group. If the number of Dox + Sul is 0.00, the fold would be shown as − 100.00