Skip to main content
Fig. 1 | Cancer Cell International

Fig. 1

From: Levetiracetam enhances the temozolomide effect on glioblastoma stem cell proliferation and apoptosis

Fig. 1

Effects of chemotherapeutic treatments on patient-derived GSC proliferation. GCSC and PCSC neurospheres derived from GBM of six different patients were treated with TMZ (250 µM), ETO (10 µM), IRI (10 µg/mL) and CARB (10 µg/mL) for 48 h. GCSCs and PCSCs proliferation rate was evaluated by BrdU incorporation. a The graph represents the distribution values of BrdU incorporation of the all neurospheres analyzed. b The graph represents BrdU incorporation of the GCSCs and PCSCs derived from patients #1, #2 and #3, that exhibit a higher capacity of BrdU incorporation. c The graph represents BrdU incorporation of the GCSCs and PCSCs derived from patients #4, #5 and #6, that exhibit a lower capacity of BrdU incorporation. K-means algorithm was used to cluster into 2 groups the BrDU incorporation values. d Percentage of decreased BrdU incorporation versus CTR. The results shown are representative of three independent experiments. ac *p < 0.05 vs CTR by Mann–Whitney test. d * p< 0.05, ** p< 0.01, ***p < 0.001 vs CTR by Student’s t-test

Back to article page