Skip to main content

Table 1 Gene ontology analysis of aberrantly methylated-differentially expressed genes in hepatocellular carcinoma

From: DNA methylation biomarkers for hepatocellular carcinoma

Category ID Term Gene count False discovery rate
Hypomethylation and high expression
 BP GO.0051983 Regulation of chromosome segregation 13 3.94E−20
 BP GO.0030071 Regulation of mitotic metaphase/anaphase transition 12 4.44E−20
 BP GO.0007094 Mitotic spindle assembly checkpoint 11 1.30E−19
 BP GO.0007088 Regulation of mitotic nuclear division 14 3.88E−19
 BP GO.0010564 Regulation of cell cycle process 17 2.77E−15
 CC GO.0000793 Condensed chromosome 10 3.89E−10
 CC GO.0005819 Spindle 11 6.30E−10
 CC GO.0031461 Cullin-RING ubiquitin ligase complex 7 1.34E−07
 CC GO.0005813 Centrosome 8 0.00011
 CC GO.0044430 Cytoskeletal part 12 0.000143
 MF GO.0048495 Roundabout binding 3 0.000105
 MF GO.0035173 Histone kinase activity 3 0.0059
 MF GO.0005515 protein binding 21 0.0083
Hypermethylation and low expression
 BP GO.0042127 Regulation of cell proliferation 15 1.97E−06
 BP GO.0010468 Regulation of gene expression 19 0.000139
 BP GO.0009968 Negative regulation of signal transduction 10 0.000642
 BP GO.0000082 G1/S transition of mitotic cell cycle 5 0.00149
 BP GO.0051726 Regulation of cell cycle 9 0.00149
 CC GO.0097458 Neuron part 10 0.00143
 CC GO.0045202 Synapse 7 0.00802
 CC GO.0070013 Intracellular organelle lumen 16 0.0137
 CC GO.0005694 Chromosome 7 0.0138
 CC GO.0005654 Nucleoplasm 13 0.0149
 MF GO.0030332 Cyclin binding 4 4.14E−05
 MF GO.0005515 Protein binding 21 0.000265
 MF GO.0004871 Signal transducer activity 11 0.00462
 MF GO.0005102 Receptor binding 10 0.00462
 MF GO.0016538 Cyclin-dependent protein serine/threonine kinase regulator activity 3 0.00462
  1. BP biological process, CC cell component, MF molecular function