DNA methylation biomarkers for hepatocellular carcinoma

Table 3 Validation of the hub genes in TCGA database

Hub gene	Methylation status	P value	Expression status	P value
Hypomethylation/high-expression
MAD2L1	Hypomethylation	< 2.2e−16	High expression	< 2.2e−16
CDC20	Hypomethylation	6.12e−13	High expression	< 2.2e−16
CCNB1	Hypomethylation	2.87e−5	High expression	< 2.2e−16
Hypermethylation/low-expression
CCND1	Hypermethylation	1.27e−5	Low expression	1.27e−5
AR	Hypermethylation	2.96e−4	Low expression	1.47e−9
ESR1	Hypermethylation	0.0258	Low expression	< 2.2e−16

ISSN: 1475-2867