Fig. 3
From: SH2B1 promotes NSCLC cell proliferation through PI3K/Akt/mTOR signaling cascade
SH2B1 promotes NSCLC cell proliferation in vivo. A total of 1 × 107 cells (A549 or H1299) were subcutaneously injected into the left dorsal flank per mouse. a SH2B1-knockdown suppressed xenograft tumor growth of A549 cells in vivo (n = 6). Upper and lower (left) panels: images of tumors from all mice in each group; lower panel (right): tumor volume (L × W2/2) was measured at internal day (*P < 0.05, t-test); b representative photographs of H&E and Ki-67 IHC staining (P = 0.005) in the indicated tumors. c SH2B1-overexpression promoted xenograft tumor growth of H1299 cells in vivo (n = 6). Upper and lower (left) panel: images of tumors from all mice in each group; lower (right) panel: tumor volume was measured at internal (*P < 0.05, t-test); d representative photographs of H&E and Ki-67 IHC staining (P = 0.004) in the indicated tumors