BC094916 suppressed SP 2/0 xenograft tumor by down-regulating Creb1 and Bcl2 transcription

Table 1 BC094916 mRNA expression decreased in TACI-IgG-regulated plasma cells

Gene symbol	Gene description	Fold change	Regulation
Prdm1	PR domain containing 1, with ZNF domain	15.73	Up
Xbp1	X-box binding protein 1	4.88	Up
Pax5	paired box gene 5	0.19	Down
Bcl6	B cell leukemia/lymphoma 6	0.20	Down
BC094916	cDNA sequence BC094916	0.14	Down

Three lupus-prone mice per group were injected i.p. with 5 mg/kg TACI-IgG or control IgG at 1, 2, 3, and 4 weeks (two times per week) after mice reached 6 months of age. On day 4 after therapy, mice were euthanized and B cells were separated from the spleen by B220 microbeads. The transcripts in B cells were determined by Affymetrix Microarrays. The fold change of the transcripts in TACI-IgG treatment to those in IgG group is shown

ISSN: 1475-2867