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Table 2 The mRNA expressions of target genes and TFs in the cross network in different molecular subtypes of GC by cBioPortal database

From: Key elements involved in Epstein–Barr virus-associated gastric cancer and their network regulation

Gene Tpye of GC Sample number mRNA expression
Mean ± SD P value
GDF5 EBVaGC 29 2.11 ± 2.52 Ref
EBVnGC 311 5.16 ± 9.55 < 0.001
    < 0.001*
EBVaGC 29 2.11 ± 2.52 Ref
GS-GC 47 10.46 ± 12.75 < 0.001
MSI-GC 62 2.12 ± 2.68 0.995
CIN-GC 202 4.85 ± 9.57 0.120
CXCL10 EBVaGC 30 6061.34 ± 6.56 Ref
EBVnGC 346 759.53 ± 1.21 < 0.001
    < 0.001*
EBVaGC 30 6061.34 ± 6.56 Ref
GS-GC 50 352.97 ± 412.44 < 0.001
MSI-GC 73 1523.12 ± 2.11 < 0.001
CIN-GC 223 600.72 ± 743.04 < 0.001
SMAD5 EBVaGC 30 1165.21 ± 557.37 Ref
EBVnGC 346 1446.01 ± 459.22 0.002
    < 0.001*
EBVaGC 30 1165.21 ± 557.37 Ref
GS-GC 50 1638.22 ± 483.08 < 0.001
MSI-GC 73 1355.35 ± 330.26 0.058
CIN-GC 223 1432.59 ± 479.20 0.003
PTGER3 EBVaGC 30 78.20 ± 91.63 Ref
EBVnGC 346 191.35 ± 235.51 < 0.001
    < 0.001*
EBVaGC 30 78.20 ± 91.63 Ref
GS-GC 50 405.75 ± 309.97 < 0.001
MSI-GC 73 101.47 ± 108.61 0.610
CIN-GC 223 172.69 ± 218.64 0.021
  1. P value for overall comparison among four subgroups