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Table 2 The mRNA expressions of target genes and TFs in the cross network in different molecular subtypes of GC by cBioPortal database

From: Key elements involved in Epstein–Barr virus-associated gastric cancer and their network regulation

Gene

Tpye of GC

Sample number

mRNA expression

Mean ± SD

P value

GDF5

EBVaGC

29

2.11 ± 2.52

Ref

EBVnGC

311

5.16 ± 9.55

< 0.001

   

< 0.001*

EBVaGC

29

2.11 ± 2.52

Ref

GS-GC

47

10.46 ± 12.75

< 0.001

MSI-GC

62

2.12 ± 2.68

0.995

CIN-GC

202

4.85 ± 9.57

0.120

CXCL10

EBVaGC

30

6061.34 ± 6.56

Ref

EBVnGC

346

759.53 ± 1.21

< 0.001

   

< 0.001*

EBVaGC

30

6061.34 ± 6.56

Ref

GS-GC

50

352.97 ± 412.44

< 0.001

MSI-GC

73

1523.12 ± 2.11

< 0.001

CIN-GC

223

600.72 ± 743.04

< 0.001

SMAD5

EBVaGC

30

1165.21 ± 557.37

Ref

EBVnGC

346

1446.01 ± 459.22

0.002

   

< 0.001*

EBVaGC

30

1165.21 ± 557.37

Ref

GS-GC

50

1638.22 ± 483.08

< 0.001

MSI-GC

73

1355.35 ± 330.26

0.058

CIN-GC

223

1432.59 ± 479.20

0.003

PTGER3

EBVaGC

30

78.20 ± 91.63

Ref

EBVnGC

346

191.35 ± 235.51

< 0.001

   

< 0.001*

EBVaGC

30

78.20 ± 91.63

Ref

GS-GC

50

405.75 ± 309.97

< 0.001

MSI-GC

73

101.47 ± 108.61

0.610

CIN-GC

223

172.69 ± 218.64

0.021

  1. P value for overall comparison among four subgroups