Fig. 3

Linc-ROR knockdown reduced cell proliferation and invasion. a Comparison of the linc-ROR levels in the cultured MCF-7 breast cancer cells with or without linc-ROR knockdown. Linc-ROR was knocked down by the si-ROR interference RNA. Cells were also untransfected (control) or transfected with a scrambled negative-control siRNA (si-nc) for comparison. b Time courses of MCF-7 proliferation. Cell proliferation rates were compared between the cells transfected with si-ROR or si-nc. The proliferation rates were quantitated every 12 h over 3 days. Linc-ROR knockdown by si-ROR led to slower proliferation. c Comparison of MCF-7 cell invasion. The cells transfected with si-ROR or si-nc were assessed in transwell assays. The scale bars are 100 μm. The data points were averaged from triplicates. **p < 0.01 vs the control. d–f Comparison of proliferation and invasion for the MDA-MB-231 breast cancer cells transfected with si-ROR or si-nc. The panels are arranged as a–c