Fig. 4

Linc-ROR knockdown reduced tumor growth in nude mice. a Time-course comparison of tumor growth from the MCF-7 cells. The cells were transfected with si-ROR or si-nc and injected into nude mice. After 14 days, tumor sizes were measured twice a week over 3 weeks. b Image of tumors harvested at day 31. c Comparison of averaged tumor weights. The tumors grown from the MCF-7 cells transfected with si-ROR were smaller. d Relative ROR expression of tumors was confirmed. The expression of ROR of tumors from the MCF cells transfected with si-ROR was inhibited. e–h Comparison of tumors derived from the MDA-MB-231 cells, which were transfected with si-ROR or si-nc and injected into nude mice. The panels are arranged as a–c. **p < 0.01 vs the control