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Fig. 3 | Cancer Cell International

Fig. 3

From: LncRNA DLX6-AS1 promoted cancer cell proliferation and invasion by attenuating the endogenous function of miR-181b in pancreatic cancer

Fig. 3

LncRNA DLX6-AS1 negatively regulated the expression of miR-181b. a The putative binding sites between DLX6-AS1 and miR-181b. b Luciferase activity was determined in HEK293T cells co-transfected with miRNAs (mimics NC or miR-181b mimics) and reporter vector containing DLX6-AS1 segments (WT or MUT) binding to miR-181b. c The expression of miR-181b in SW1990 and PANC-1 cells transfected with siNC or siDLX6-AS1 was determined by qRT-PCR. d The expression of miR-181b was down-regulated in pancreatic cancer tissues (n = 84) compared to normal adjacent pancreatic cancer tissues (n = 84). e The correlation between miR-181b expression and DLX6-AS1 expression in pancreatic cancer tissues was analyzed by Spearman’s correlation test (r = − 0.3242, P = 0.0026). **P < 0.01 and ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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