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Table 2 Univariate and multivariate Cox regression of clinical characteristics and inflammatory biomarkers in 153 esophageal squamous cell carcinoma patients

From: The predictive and prognostic role of a novel ADS score in esophageal squamous cell carcinoma patients undergoing esophagectomy

Variables

Three years’ OS

Univariate analysis

Multivariate analysis

HR (95% CI)

p-value

Adjusted HR (95% CI)a

p-value

Gender (male)

1.787 (0.927–3.445)

0.083

–

–

Age (≥ 60 years)

1.017 (0.663–1.559)

0.940

–

–

Tobacoo (yes)

1.093 (0.727–1.643)

0.670

–

–

Alcohol (yes)

1.065 (0.703–1.614)

0.767

–

–

Hypertension (yes)

1.102 (0.482–2.522)

0.818

–

–

Diabetes (yes)

20.837 (0.042–10283.099)

0.337

–

–

Tumor stage (III)

1.460 (0.945–2.256)

0.088

–

–

Depth of invasion (T3)

2.523 (1.366–4.661)

0.003

3.622 (1.591–8.242)

0.002

Lympth node (yes)

1.086 (0.717–1.645)

0.098

–

–

Differentiation (poor)

2.041 (1.008–4.131)

0.047

1.579 (0.641–3.889)

0.321

Tumor size (≥ 4 cm)

1.413 (0.910–2.193)

0.124

–

–

Radio-chemotherapy (yes)

1.444 (0.812–2.566)

0.211

–

–

NLR (≥ 2.1)

1.495 (0.967–2.311)

0.070

–

–

PLR (≥ 145.9)

1.640 (1.085–2.479)

0.019

1.964 (1.129–3.415)

0.017

LMR (< 2.3)

2.066 (1.166–3.663)

0.013

1.445 (0.669–3.115)

0.349

dNLR (≥ 4.3)

2.387 (1.515–3.761)

< 0.001

2.338 (1.626–5.308)

< 0.001

Fib (≥ 3.2 mg/dL)

1.886 (1.242–2.866)

0.003

2.148 (1.229–3.753)

0.007

Alb (< 38.2 g/L)

1.969 (1.266–3.058)

0.003

2.398 (1.342–4.273)

0.003

AFR (< 9.3)

1.953 (1.175–3.247)

0.010

2.381 (1.152–4.926)

0.019

  1. OS overall survival, HR hazard ratio, CI confidence interval, NLR neutrophil to lymphocytes ratio, dNLR derived neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, LMR lymphocyte to monocyte ratio, Fib fibrinogen, Alb albumin, AFR albumin to fibrinogen ratio
  2. aAdjusted by sex, age, alcohol, tobacco, hypertension, diabetes, radio-chemotherapy, tumor size, tumor grade and tumor stage