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Fig. 3 | Cancer Cell International

Fig. 3

From: BORIS: a key regulator of cancer stemness

Fig. 3

Role of BORIS as an epigenetic modifier regulating the expression of multiple proto-oncogenes and CT genes. BORIS recruits histone modifier complexes to the promoter of target genes to induce tri-methylation of lysine 4 of histone H3 tail, and methylation of arginine and acetylation of lysine 14 of histone H3 tail. BORIS also is involved in promoter methylation/demethylation of target genes. Therefore, BORIS creates a permissive/active chromatin conformation via epigenetic modifications that lead to the upregulation of target genes such as CT genes, Oct4 and Notch3

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