Table 1 Enrichment analyses for DEGs
From: Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC
Category | Term | Description | P value | Genes |
|---|---|---|---|---|
(a) GO functional analysis for upregulated DEGs | ||||
 BP | GO:0001822 | Kidney development | 1.89 × 10− 4 | SULF1, ITGA8, etc |
 BP | GO:0043066 | Negative regulation of apoptotic process | 4.92 × 10−3 | GCLC, CD38, etc |
 BP | GO:0045779 | Negative regulation of bone resorption | 5.80 × 10−3 | CALCA, CD38, etc |
 BP | GO:0000302 | Response to reactive oxygen species | 6.35 × 10−3 | GPX2, GSR, etc |
 BP | GO:0038083 | Peptidyl-tyrosine autophosphorylation | 6.82 × 10−3 | FRK, LYN, etc |
 BP | GO:0009725 | Response to hormone | 7.81 × 10−3 | GCLC, LYN, etc |
 BP | GO:0045892 | Negative regulation of transcription, DNA-templated | 9.56 × 10−3 | CD38, GCLC, etc |
 BP | GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | 1.43 × 10−2 | FRK, LYN, etc |
 BP | GO:0002250 | Adaptive immune response | 1.48 × 10−2 | LYN, LAX1, etc |
 BP | GO:0050853 | B cell receptor signaling pathway | 1.55 × 10−2 | CD38, LYN, etc |
 CC | GO:0005576 | Extracellular region | 1.72 × 10−4 | CER1, C3, etc |
 CC | GO:0005615 | Extracellular space | 5.81 × 10−3 | CER1, SELP, etc |
 CC | GO:0048471 | Perinuclear region of cytoplasm | 7.73 × 10−3 | SYT4, LYN, etc |
 CC | GO:0005886 | Plasma membrane | 9.00 × 10−3 | SYT4, CDCP1, etc |
 CC | GO:0070062 | Extracellular exosome | 1.21 × 10−2 | FRK, TSPAN1, etc |
 CC | GO:0031234 | Extrinsic component of cytoplasmic side of plasma membrane | 2.85 × 10−2 | FRK, LYN, etc. |
 CC | GO:0016942 | Insulin-like growth factor binding protein complex | 2.89 × 10−2 | IGF1, IGFBP5 |
 CC | GO:0042567 | Insulin-like growth factor ternary complex | 3.83 × 10−2 | IGF1, IGFBP5 |
 CC | GO:0005604 | Basement membrane | 4.16 × 10−2 | MATN2, CCDC80, etc |
 CC | GO:0005578 | Proteinaceous extracellular matrix | 4.69 × 10−2 | P3H1, OGN, etc |
 MF | GO:0005509 | Calcium ion binding | 2.70 × 10−4 | ME3, SYT4, etc |
 MF | GO:0008201 | Heparin binding | 1.08 × 10−3 | OGN, SELP, etc. |
 MF | GO:0032403 | Protein complex binding | 4.45 × 10−3 | CALCA, FYB, etc |
 MF | GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | 1.06 × 10−2 | FRK, LYN, etc |
 MF | GO:0033040 | Sour taste receptor activity | 1.97 × 10−2 | PKD2L1, PKD1L3 |
 MF | GO:0004222 | Metalloendopeptidase activity | 2.59 × 10−2 | ADAM28, MME, etc |
 MF | GO:0016668 | Oxidoreductase activity, acting on a sulfur group of donors, NAD (P) as acceptor | 3.90 × 10−2 | GSR, TXNRD1 |
 MF | GO:0043208 | Glycosphingolipid binding | 3.90 × 10−2 | SELP, LYN |
 MF | GO:0008237 | Metallopeptidase activity | 4.63 × 10−2 | ADAM28, MME, etc. |
 MF | GO:0000988 | Transcription factor activity, protein binding | 4.85 × 10−2 | HEY1, SMAD3 |
(b) GO analysis for downregulated DEGs | ||||
 BP | GO:0007399 | Nervous system development | 2.57 × 10−6 | ZC4H2, PCDHB6, etc |
 BP | GO:0007156 | Homophilic cell adhesion via plasma membrane adhesion molecules | 4.09 × 10−6 | CDH7, FAT1, etc |
 BP | GO:0007268 | Chemical synaptic transmission | 1.12 × 10−4 | CBLN1, PCDHB6, etc |
 BP | GO:0007155 | Cell adhesion | 2.53 × 10−4 | EFNB2, SPOCK1, etc |
 BP | GO:0001764 | Neuron migration | 1.39 × 10−3 | ASTN1, RELN, etc |
 BP | GO:0007411 | Axon guidance | 8.18 × 10−3 | NEO1, CDH4, etc |
 BP | GO:0007416 | Synapse assembly | 1.20 × 10−2 | ADGRL3, PCDHB10, etc |
 BP | GO:0051965 | Positive regulation of synapse assembly | 1.26 × 10−2 | LRRN3, LRRN1, |
 BP | GO:0016339 | Calcium-dependent cell–cell adhesion via plasma membrane cell adhesion molecules | 2.00 × 10−2 | PCDHB6, PCDHB11, etc |
 BP | GO:0045666 | Positive regulation of neuron differentiation | 2.31 × 10−2 | SOX11, MMD, etc |
 CC | GO:0005887 | Integral component of plasma membrane | 4.14 × 10−4 | GRIK2, MET, etc |
 CC | GO:0045211 | Postsynaptic membrane | 4.08 × 10−3 | CBLN1, ZC4H2, etc |
 CC | GO:0005886 | Plasma membrane | 1.17 × 10−2 | GRIK2, FHL1, etc |
 CC | GO:0031941 | Filamentous actin | 2.05 × 10−2 | MYO6, FSCN1, etc |
 CC | GO:0030424 | Axon | 2.15 × 10−2 | STMN2, CNR1, etc |
 CC | GO:0030425 | Dendrite | 3.31 × 10−2 | RELN, GNG3, etc |
 CC | GO:0000788 | Nuclear nucleosome | 3.93 × 10−2 | HIST1H2BB, HIST1H3C, etc |
 CC | GO:0043204 | Perikaryon | 4.02 × 10−2 | ASTN1, KCNK1, etc |
 CC | GO:0034705 | Potassium channel complex | 4.21 × 10−2 | KCNA6, KCNK1 |
 CC | GO:0030054 | Cell junction | 4.64 × 10−2 | ZC4H2, GRIK2, etc |
 MF | GO:0005509 | Calcium ion binding | 6.10 × 10−3 | CDH7, DGKB, etc |
 MF | GO:0032051 | Clathrin light chain binding | 3.60 × 10−2 | NSG1, HMP19 |
 MF | GO:0009931 | Calcium-dependent protein serine/threonine kinase activity | 5.00 × 10−2 | CAMK4, DCX |
Term | Description | Count | P value | Key genes |
|---|---|---|---|---|
(c) KEGG pathway analysis for downregulated DEGs | ||||
 hsa05202 | Transcriptional misregulation in cancer | 6 | 1.64 × 10−3 | HIST1H3J, EYA1, MET, ETV1, HIST1H3C, MEIS1 |
 hsa04360 | Axon guidance | 5 | 4.07 × 10−3 | EPHA4, PAK3, EFNB2, MET, DPYSL5 |
 hsa05034 | Alcoholism | 5 | 1.29 × 10−2 | HIST1H3J, HIST1H2BB, CAMK4, HIST1H3C, GNG3 |
 hsa04723 | Retrograde endocannabinoid signaling | 4 | 1.53 × 10−2 | SLC32A1, GABRG2, CNR1, GNG3 |
 hsa05322 | Systemic lupus erythematosus | 4 | 3.20 × 10−2 | HIST1H3J, HIST1H2BB, HIST1H3C, HLA-DQA1 |