Table 3 Enrichment analyses for DEGs in the PPI network and subnetwork module a
From: Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC
Term | Description | Count | P value | Key genes |
|---|---|---|---|---|
PPI | ||||
 GO:0042592 | Homeostatic process | 6 | 5.44 × 10−5 | CALCA, GSR, LYN, IGF1, TXNRD1, GNG3 |
 GO:0042325 | Regulation of phosphorylation | 5 | 1.53 × 10−4 | CALCA, PRKAR2B, LYN, IGF1, GNG3 |
 GO:0019220 | Regulation of phosphate metabolic process | 5 | 1.78 × 10−4 | CALCA, PRKAR2B, LYN, IGF1, GNG3 |
 GO:0051174 | Regulation of phosphorus metabolic process | 5 | 1.78 × 10−4 | CALCA, PRKAR2B, LYN, IGF1, GNG3 |
 GO:0009725 | Response to hormone stimulus | 4 | 1.47 × 10−3 | PRKAR2B, LYN, MGP, GNG3 |
 GO:0009719 | Response to endogenous stimulus | 4 | 1.96 × 10−3 | PRKAR2B, LYN, MGP, GNG3 |
 GO:0019725 | Cellular homeostasis | 4 | 2.92 × 10−3 | CALCA, GSR, TXNRD1, GNG3 |
 GO:0043085 | Positive regulation of catalytic activity | 4 | 3.99 × 10−3 | CALCA, PRKAR2B, GNG3, CAP1 |
 GO:0001932 | Regulation of protein amino acid phosphorylation | 3 | 5.52 × 10−3 | PRKAR2B, LYN, IGF1 |
 GO:0044093 | Positive regulation of molecular function | 4 | 5.58 × 10−3 | CALCA, PRKAR2B, GNG3, CAP1 |
Module a | ||||
 GO:0007186 | G-protein coupled receptor protein signaling pathway | 4 | 2.14 × 10−3 | C3, GRM8, CNR1, GNG3 |
 GO:0007166 | Cell surface receptor linked signal transduction | 4 | 9.26 × 10−3 | C3, GRM8, CNR1, GNG3 |
 GO:0050727 | Regulation of inflammatory response | 2 | 2.23 × 10−2 | C3, SAA1 |
 GO:0002526 | Acute inflammatory response | 2 | 2.87 × 10−2 | C3, SAA1 |
 GO:0007204 | Elevation of cytosolic calcium ion concentration | 2 | 3.21 × 10−2 | SAA1, GNG3 |
 GO:0051480 | Cytosolic calcium ion homeostasis | 2 | 3.44 × 10−2 | SAA1, GNG3 |
 GO:0032101 | Regulation of response to external stimulus | 2 | 4.62 × 10−2 | C3, SAA1 |