Fig. 6
From: R-spodin2 enhances canonical Wnt signaling to maintain the stemness of glioblastoma cells
Wnthigh tumors grow faster and have high RSPO expression. a 1 × 104 Wnthigh or Wntlow cells were inoculated at the flanks of nude mice, and tumor growth curve were recorded. The result shows that Wnthigh cell-injected xenografts (n = 9) grow faster than Wntlow cell-injected xenografts (n = 6). b Protein expression of β-catenin targets, RSPO/LGR, EMT markers and differentiation marker was compared between Wnthigh (n = 4) and Wntlow (n = 4) xenografts. c Statistic analysis of G. d Tumor sections from Wnthigh or Wntlow xenografts were stained by RSPO2, LGR4 and CCND1, where Wnthigh tumors display stronger staining compared to Wntlow tumors. Scale bar is 200 μm