Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis

Wen, Jing; Xu, Qian; Yuan, Yuan

doi:10.1186/s12935-018-0656-2

Cancer Cell International

Table 1 Genetic variants associated with NHCRC after meta-analyses of at least three independent datasets (primary meta-analyses)

From: Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis

Gene	SNPs	Chr	Alleles^a	Datasets	Cases	Controls	OR	CI-U	CI-L	P	FDR	Venice criteria	Level of evidence
BMP2	rs961253	20	C-A	23	40507	40740	1.121	1.098	1.144	7.77E−27	7.15E−25	AAA	High
CASC8	rs10505477	8	T-C	13	12933	13259	0.856	0.828	0.886	9.27E−19	2.84E−17	AAA	High
BMP4	rs4444235	14	T-C	27	39030	39934	1.083	1.061	1.105	8.24E−15	1.89E−13	AAA	High
SMAD7	rs12953717	18	C-T	9	10782	10011	1.163	1.118	1.209	4.93E−14	8.00E−13	AAA	High
CCAT2	rs6983267	8	G-T	26	33098	30415	0.845	0.807	0.884	3.35E−13	3.86E−12	AAA	High
TGF-β1	rs1800469	19	C-T	21	17404	36234	0.911	0.887	0.936	1.59E−11	1.62E−10	AAA	High
LOC105376400	rs10795668	10	G-A	8	5744	5481	0.837	0.791	0.886	8.43E−10	5.27E−09	AAA	High
GREM1-SCG5	rs4779584	15	C-T	16	25151	24548	1.154	1.093	1.217	1.69E−07	8.62E−07	AAA	High
ADIPOQ	rs2241766	3	T-G	7	2400	2972	1.216	1.115	1.326	9.33E−06	3.07E−05	AAA	High
miR-27a	rs895819	19	T-C	5	1562	1852	1.192	1.076	1.320	0.001	0.002	AAA	High
ADIPOR1	rs1342387	1	G-A	5	1843	2563	0.824	0.755	0.900	1.82E−05	5.76E−05	ABA	Intermediate
ICAM1	rs5498 469	19	A-G	3	358	335	0.740	0.595	0.920	0.007	0.012	BAA	Intermediate
PARP-1	rs1136410	1	T-C	3	808	1849	1.181	1.043	1.337	0.009	0.015	ABA	Intermediate
RHPN2	rs10411210	19	C-T	15	22299	23280	0.881	0.844	0.919	6.12E−09	4.69E−08	ABC	Low
SMAD7	rs4464148	18	T-C	8	9736	8573	1.142	1.091	1.196	1.62E−08	1.15E−07	AAC	Low
SMAD7	rs4939827	18	T-C	17	16336	15443	0.859	0.813	0.908	5.94E−08	3.42E−07	ACA	Low
CDH1	rs9929218	16	G-A	17	22459	24079	0.930	0.903	0.958	1.51E−06	5.80E−06	AAC	Low
COLCA1	rs3802842	11	A-C	18	18043	17876	1.149	1.086	1.216	1.62E−06	5.97E−06	ACC	Low
NA	rs719725	9	A-C	14	11820	13119	0.934	0.900	0.968	2.17E−04	5.56E−04	AAC	Low
MLH1	rs63750447	3	T-A	6	1427	1491	2.449	1.426	4.205	0.001	0.002	CCC	Low
XPG	rs17655	13	G-C	8	4752	5648	1.101	1.036	1.170	0.002	0.004	AAC	Low
NAT2	rs1801280	8	T-C	3	2066	2581	0.876	0.807	0.952	0.002	0.004	AAC	Low
NA	rs11568820	12	G-A	5	4278	4693	1.112	1.036	1.194	0.003	0.006	AAC	Low
VDR	rs1544410	12	G-A	14	10404	11213	0.768	0.633	0.930	0.007	0.012	ACC	Low
CCND1	rs9344	11	G-A	21	4757	6680	1.119	1.026	1.220	0.011	0.017	ACC	Low
CDH1	rs16260	16	C-A	8	6062	7045	0.934	0.884	0.988	0.016	0.023	AAC	Low
EGF	rs4444903	4	G-A	8	1234	1377	0.819	0.692	0.969	0.020	0.027	ACC	Low
GREM1	rs16969681	15	C-T	6	7300	9039	1.157	1.022	1.311	0.021	0.028	ACA	Low
MTRR	rs1801394	5	A-G	19	8409	11893	1.046	1.004	1.089	0.030	0.036	ABC	Low
NQO1	rs1800566	16	C-T	13	6016	6905	1.142	1.013	1.288	0.030	0.036	ACC	Low
MMP9	rs3918242	20	C-T	5	829	1096	0.803	0.657	0.980	0.031	0.037	BAC	Low
ERCC1	rs11615	19	C-T	5	982	1251	1.147	1.011	1.302	0.033	0.037	AAC	Low
APC	rs459552	5	A-T	13	9440	10200	0.950	0.905	0.997	0.037	0.041	AAC	Low
CYP1A1	rs1048943	15	A-G	13	3509	3960	1.287	1.011	1.637	0.040	0.043	ACA	Low
GH1	rs2665802	17	T-A	3	2740	3198	0.929	0.863	0.999	0.046	0.047	AAC	Low
RETN	rs1862513	19	C-G	3	1013	1049	1.145	1.000	1.311	0.050	0.050	ABC	Low

Chr chromosome, FDR false discovery rate
^aMajor alleles-minor alleles; Venice criteria: A (high), B (moderate), C (weak) credibility for three parameters (amount of evidence, heterogeneity and bias; see text and Additional file 1 for more details); level of evidence: overall level of summary evidence according to the Venice criteria

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