Fig. 3

Effects of a forced reversal of the PON3 levels on the drug resistance of K510 cells. The levels of PON3 mRNA (a) and protein level (b) determined by qRT-PCR and western blot analysis in the eight esophageal cancer cell lines. The levels of protein level (c) PON3 and mRNA (d) determined by western blot and qRT-PCR analysis in the si-PON3-transfected versus the NC-transfected K510. The cell death triggered by an IC₅₀ dose of four drugs in K510 cells transfected with the si-PON3-transfected versus the negative control (NC) assayed 72 h after treatment with the IC₅₀ dose of drugs (e)