Skip to main content
Fig. 7 | Cancer Cell International

Fig. 7

From: Paraoxonase 3 is involved in the multi-drug resistance of esophageal cancer

Fig. 7

Effect of PON3 on the in vivo growth and DDP drug resistance of K510-derived xenografts in nude mice. a Experimental scheme: K510 cells were subcutaneously injected at two points on the back of each nude mouse, with 2 sites/mouse, 6 mice for K510. From the 15th day after cell injection, all six K150-generated tumors on the left back of the nude mice were intratumorally injected with 2nM si-PON3, and the six right back sites were injected with 2 nM Mock; this process was repeated four times within 3 days. From the 28th day after cell injection, 3 K510 mice received DDP (2.5 mg/kg) intraperitoneally once every 3 days, for a total of 4 injections over 12 days. The remaining 3 mice received PBS as a mock treatment control. b Image of representative tumors on the day of 45, and the mean ± SD of the tumor weight of the tumor for the same treatment was calculated, plotted and summarized. c The protein levels of PON3 and Ki67 in each group were determined by immunostaining and summarized in the table (Magnification: ×200)

Back to article page