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Fig. 1 | Cancer Cell International

Fig. 1

From: RETRACTED ARTICLE: Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC-1 cell apoptosis via activating the mROS-HtrA2/Omi pathways

Fig. 1

Erlotinib promotes PANC-1 apoptosis in a concentration-dependent fashion. a The MTT assay for PANC-1 viability. Different doses of erlotinib were added to the medium of PANC-1 cells. b LDH release was used to evaluate the cell death in PANC-1 cells in the presence of erlotinib. c The MTT assay for PaCa-2 cells in the presence of erlotinib treatment. d LDH release was used to evaluate the cell death in PaCa-2 cells in the presence of erlotinib. e TUNEL staining for apoptotic PANC-1 cells and PaCa-2 cells. The number of TUNEL-positive cells was recorded. f Quantification of the TUNEL assay in PANC-1 cells. g The TUNEL assay for PaCa-2 cells in response to erlotinib treatment. The percentage of TUNEL-positive PaCa-2 cells was recorded. h, i Caspase-3 activity was determined using an ELISA in PANC-1 cells and PaCa-2 cells. #p < 0.05 vs. control group

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