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Fig. 6 | Cancer Cell International

Fig. 6

From: RETRACTED ARTICLE: Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC-1 cell apoptosis via activating the mROS-HtrA2/Omi pathways

Fig. 6

Mitochondrial fragmentation regulates the proliferation of PANC-1 cells via the mROS-HtrA2/Omi pathways. a The EdU assay was used to observe the cellular proliferation in response to erlotinib treatment. Mdivi-1 was used to inhibit mitochondrial fragmentation. Furthermore, two siRNAs against HtrA2/Omi were transfected into PANC-1 cells to suppress HtrA2/Omi expression. Additionally, mitoQ was added into the medium of PANC-1 cells to attenuate the production of mROS. b The quantification of EdU-positive cells. c–e CDK4 and Cyclin D1 expression were evaluated via western blotting. Mdivi-1 was used to inhibit mitochondrial fragmentation. In addition, two siRNAs against HtrA2/Omi were transfected into PANC-1 cells to suppress HtrA2/Omi expression. Furthermore, mitoQ was added to the medium of PANC-1 cells to attenuate the production of mROS. *p < 0.05

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Cancer Cell International

ISSN: 1475-2867

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