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Fig. 8 | Cancer Cell International

Fig. 8

From: Genome editing of oncogenes with ZFNs and TALENs: caveats in nuclease design

Fig. 8

TALEN-mediated editing resulted in the reduction of E7 protein in both SiHa and CaSki cells. Immunocytochemical analysis revealed that levels of E7 protein was reduced in TALEN-treated (C, D) when compared to control (A, B) SiHa cells. Similarly, a reduction in E7 levels was observed in CaSki cells also after TALEN treatment (G, H) than in its respective control cells (E, F). This was further confirmed by Western blot analysis which showed a significant reduction in the levels of E7 after TALEN treatment in both the cell lines (I). Magnification-×600

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