Table 2 Main characteristics of studies included in this meta-analysis
First author | Publication year | Case nationality | Dominant ethnicity | Median or mean age | Study design | Malignant disease | Main type of pathology | Detected sample | Assay method | Survival analysis | Source of HR | Maximum months of follow-up |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Chou [20] | 2018 | China | Asian | 50 | R | Glioblastoma multiforme | Glioma | Tissue | ihc | OS/PFS | Reported | 207 |
Lu [10] | 2017 | China | Asian | 60 | R | Colorectal cancer | AdenoCa | Tissue | ihc | OS | SC | 40 |
Huang [4] | 2017 | China | Asian | 60 | R | Colorectal cancer | AdenoCa | Tissue | ihc | OS | Reported | 50 |
Li [11] | 2017 | China | Asian | 40 | R | Cervical carcinoma | SqCa | Tissue | ihc | OS | Reported | 78 |
Shimuraa [41] | 2017 | Japan | Asian | 55 | R | Biliary cancer | AdenoCa | Serum | ELISA | OS | Reported | 69.9 |
Shimurab [41] | 2017 | Japan | Asian | 55 | R | Pancreatic cancer | AdenoCa | Serum | ELISA | OS | Reported | 66 |
Wang [49] | 2017 | China | Asian | NM | R | Ovarian cancer | SqCa | Tissue | ihc | OS | Reported | 72 |
Liu [37] | 2017 | China | Asian | 65.1 | R | Colorectal cancer | AdenoCa | Tissue | ihc | DFS | Reported | 60 |
Gopalan [21] | 2016 | Australia | Caucasian | 60 | R | Colorectal cancer | AdenoCa | Tissue | ihc | OS | SC | 110 |
Ilmer [12] | 2016 | American | Caucasian | 47 | R | Breast cancer | AdenoCa | Tissue | ihc | OS | SC | 232 |
Yang [48] | 2016 | China | Asian | 66.8 | R | Colorectal cancer | AdenoCa | tissue | ihc | DFS | Reported | 60 |
Tas [36] | 2016 | Turkey | Caucasian | 59.5 | R | Gastric cancer | AdenoCa | Serum | ELISA | OS | SC | 97 |
Cheng [40] | 2015 | China | Asian | 55.2 | R | Gastric cancer | AdenoCa | Serum | ELISA | OS | SC | 60 |
Lu [47] | 2015 | China | Asian | 51 | R | Ovarian cancer | SqCa | Tissue | ihc | OS | Reported | 77 |
Jiang [22] | 2014 | China | Asian | 50 | R | Hepatocellular carcinoma | AdenoCa | Tissue | ihc | OS | Reported | 87 |
Gomes [23] | 2014 | Brazil | Caucasian | 50 | R | Gastric cancer | AdenoCa | Tissue | ihc | OS | SC | 55 |
Mu [44] | 2013 | China | Asian | 66 | R | Gastric cancer | AdenoCa | Tissue | ihc | OS | Reported | NM |
Wu [45] | 2013 | China | Asian | 59.6 | R | Non-small cell lung cancer | SqCa | Tissue | ihc | OS | Reported | 90 |
Liu [46] | 2013 | China | Asian | 57.1 | R | Non-small cell lung cancer | SqCa | Tissue | ihc | OS | SC | 80 |
Yamaki [24] | 2012 | Japan | Asian | 53 | R | Breast cancer | AdenoCa | Tissue | ihc | OS/PFS | SC | 13 |
Yang [25] | 2012 | China | Asian | 45 | R | Gallbladder carcinoma | AdenoCa | Tissue | ihc | OS | SC | 18 |
Kim [26] | 2012 | Korea | Asian | 60 | R | Gastric cancer | AdenoCa | Tissue | ihc | OS | Reported | 96 |
Kosacka [38] | 2011 | Poland | Caucasian | 59.3 | R | Non-small cell lung cancer | SqCa | Tissue | ihc | OS | SC | 24 |
Povegliano [27] | 2010 | Brazil | Caucasian | 50 | R | Colorectal cancer | AdenoCa | Tissue | ihc | OS | SC | 83 |
Canesin [42] | 2010 | American | Caucasian | NM | R | Bladder cancer | SqCa | Tissue | ihc | OS | SC | 173 |
Vereecken [43] | 2009 | American | Caucasian | 60 | R | Melanoma | NM | Serum | ELISA | OS | Reported | 60 |
Miranda [28] | 2009 | Brazil | Caucasian | 59 | R | Laryngeal carcinoma | SqCa | Tissue | ihc | DFS | SC | 166 |
Szoke [29] | 2007 | German | Caucasian | 58.8 | R | Non-small cell lung cancer | SqCa | Tissue | ihc | OS | SC | 127 |
Kang [30] | 2007 | Korea | Asian | 63 | R | Esophageal cancer | SqCa | Tissue | ihc | OS | SC | 108 |
Moisa [39] | 2007 | Germany | Caucasian | 56.8 | R | Breast cancer | AdenoCa | Tissue | ihc | OS/DFS | Reported | 185 |
Okada [13] | 2006 | Japan | Asian | 63.9 | R | Gastric cancer | AdenoCa | tissue | ihc | OS | Reported | 72 |
Plzak [31] | 2004 | Prague | Caucasian | 60 | R | Head and neck carcinoma | SqCa | Tissue | ihc | OS | SC | 60 |
Piantelli [14] | 2002 | Rome | Caucasian | 60 | R | Laryngeal carcinoma | SqCa | Tissue | ihc | OS/RFS | SC | 90 |
Brule [32] | 2000 | Belgium | Caucasian | 65 | R | Prostate carcinomas | AdenoCa | Tissue | ihc | PFS | SC | 86 |
Honjo [33] | 2001 | Japan | Asian | 60 | R | Tongue carcinoma | SqCa | Tissue | ihc | OS/DFS | SC | 118 |
Nakamura [34] | 1999 | Japan | Asian | NM | R | Colorectal cancer | AdenoCa | Tissue | ihc | OS/DFS | SC | 103 |
Sanjuan [35] | 1997 | Spain | Caucasian | NM | R | Colorectal cancer | AdenoCa | Tissue | ihc | OS/RFS | SC | 96 |