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Fig. 5 | Cancer Cell International

Fig. 5

From: MicroRNA-218-5p inhibits cell growth and metastasis in cervical cancer via LYN/NF-κB signaling pathway

Fig. 5

LYN was a direct target of miR-218-5p. a Schema of pMIR-REPORT vectors for the luciferase assay. b Relative luciferase activity in HeLa cells. LYN-WT + miR-218-5p showed a significant decrease. *P < 0.05, compared with other group. c The expressions of mRNA and protein of LYN were decrease transfected with miR-218-5p mimics. *P < 0.05, compared with the NC group. d The expression of mRNA and protein of LYN were decrease transfected with si-LYN. Co-transfected si-LYN + miR-218-5p inhibitor group had no change. *P < 0.05, compared with NC group. e The expression of miR-218-5p had no change when affected LYN expression. f LYN promoted cell proliferation in CC. g Colony formation assay was used to detect the effect of LYN for HeLa cell proliferation. *P < 0.05, compared with NC group

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Cancer Cell International

ISSN: 1475-2867

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