Fig. 7

Overexpression LYN activated NF-κB signaling pathway and promoted tumor formation in vivo. a The protein level of NF-κB p65, p NF-κB p65, IκBα and p IκBα was detected by Western blot. b p NF-κB p65/NF-κB p65 ratio decreased in si-LYN group. *P < 0.05, compared with NC group. And p NF-κB p65/NF-κB p65 was unchanged in si-LYN + miR-218-5p inhibitor group (c) p IκBα/IκBα ratio decreased when transfected with si-LYN. And p IκBα/IκBα was unchanged in si-LYN + miR-218-5p inhibitor group. *P < 0.05, compared with NC group. d Effects of LYN on tumor growth of CC xenograft in nude mice. e The volume was smaller in si-LYN group and larger in pCDNA3.1-LYN group. *P < 0.05, compared with NC group. f The weight was lighter in si-LYN group and heavier in pCDNA3.1-LYN group. *P < 0.05, compared with NC group. g The expression of miR-218-5p was lower in si-LYN + miR-218-5p inhibitor group in mice tumor tissues. *P < 0.05, compared with NC group. h The expression of LYN was lower in si-LYN group and was higher in pCDNA3.1-LYN group in mice tumor tissues. *P < 0.05, compared with NC group