TEAD4 overexpression promotes epithelial-mesenchymal transition and associates with aggressiveness and adverse prognosis in head neck squamous cell carcinoma

Table 2 Univariate and multivariate survival analyses (proportional hazards method) for patients with primary HNSCC

Variable	Univariate survival analysis			Multivariate survival analysis
Variable	Hazard ratio	95% CI	P-value	Hazard ratio	95% CI	P-value
Gender (male, female)	0.701	0.299–1.645	0.415			N/A
Smoking (No, Yes)	0.958	0.409–2.243	0.922			N/A
Alcohol use (No, Yes)	0.651	0.255–1.660	0.369			N/A
Age (≤ 60, > 60)	0.995	0.429–2.307	0.991	0.944	0.405–2.202	0.895
Tumorsize (T1–T2, T3–T4)	0.591	0.261–1.336	0.206	2.010	0.535–7.547	0.301
Pathological grade (I, II–III)	0.587	0.260–1.327	0.200	0.909	0.366–2.261	0.838
Cervical nodal metastasis (N0, N +)	0.540	0.238–1.225	0.140	1.816	0.483–6.832	0.377
Clinical stage (I–II, III–IV)	0.311	0.123–0.788	0.014	0.194	0.038–0.998	0.050
TEAD4 expression (low, high)	0.029	0.115–0.732	0.009	0.344	0.133–0.893	0.028

The numbers in italic indicate statistical significance with P-values less than 0.05

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