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Table 1 Association between polymorphisms and risk of gastric cancer

From: Polymorphisms of TGFBR1, TLR4 are associated with prognosis of gastric cancer in a Chinese population

Polymorphism Genotype Cases, n (%) Controls, n (%) OR (95% CI) OR (95% CI)a p value
IL-16 rs4072111 CC 334 (69.73) 345 (71.43) Reference Reference  
TC 126 (26.30) 122 (25.26) 1.07 (0.80,1.43) 1.01 (0.75,1.36) 0.970
TT 19 (3.97) 16 (3.31) 1.23 (0.62,2.43) 1.20 (0.60,2.41) 0.600
TC/TT 145 (30.27) 138 (28.57) 1.09 (0.82,1.43) 1.02 (0.77,1.36) 0.870
Additive model    1.08 (0.86,1.37) 1.04 (0.82,1.32) 0.755
rs4778889 TT 267 (55.74) 266 (55.07) Reference Reference  
CT 182 (38.00) 192 (39.75) 0.94 (0.73,1.23) 0.92 (0.70,1.20) 0.524
CC 30 (6.26) 25 (5.18) 1.20 (0.68,2.09) 1.19 (0.68,2.10) 0.542
CT/CC 212 (44.26) 217 (44.93) 0.97 (0.76,1.26) 0.95 (0.73,0.23) 0.688
Additive model    1.01 (0.82,1.25) 1.00 (0.81,1.23) 0.965
rs859 TT 129 (26.93) 124 (25.67) Reference Reference  
CT 235 (49.06) 248 (51.35) 0.91 (0.67,1.24) 0.88 (0.64,1.20) 0.406
CC 115 (24.01) 111 (22.98) 1.00 (0.70,1.43) 0.98 (0.68,1.41) 0.899
CT/CC 350 (73.07) 359 (74.33) 0.94 (0.70,1.25) 0.92 (0.68,1.23) 0.551
Additive model    1.00 (0.83,1.19) 0.98 (0.82,1.18) 0.859
rs11556218 TT 306 (63.88) 308 (63.77) Reference Reference  
GT 151 (31.52) 157 (32.51) 1.97 (0.74,1.27) 0.93 (0.71,1.23) 0.628
GG 22 (4.59) 18 (3.73) 1.23 (0.65,2.34) 1.29 (0.68,2.48) 0.439
GT/GG 173 (36.12) 175 (36.23) 1.00 (0.77,1.29) 0.97 (0.94,1.27) 0.820
Additive model    1.02 (0.82,1.28) 1.01 (0.81,1.27) 0.913
rs1131445 TT 221 (46.14) 210 (43.48) Reference Reference  
CT 211 (44.05) 222 (45.96) 0.90 (0.69,1.18) 0.94 (0.72,1.23) 0.655
CC 47 (9.81) 51 (10.56) 0.88 (0.57,1.36) 0.93 (0.59,1.46) 0.748
CT/CC 258 (53.86) 273 (56.52) 0.90 (0.70,1.16) 0.93 (0.72,1.21) 0.592
Additive model    0.92 (0.76,1.12) 0.95 (0.78,1.16) 0.618
TLR4 rs10759932 TT 240 (50.10) 251 (51.97) Reference Reference  
TC 191 (39.87) 196 (40.58) 1.02 (0.78,1.33) 1.05 (0.80,1.38) 0.733
CC 48 (10.02) 36 (7.45) 1.39 (0.87,2.22) 1.38 (0.86,2.23) 0.184
TC/CC 239 (49.90) 232 (48.03) 1.08 (0.84,1.39) 1.10 (0.85,1.42) 0.481
Additive model    1.11 (0.91,1.35) 1.12 (0.92,1.36) 0.275
rs1927911 GG 171 (35.70) 175 (36.23) Reference Reference  
GA 226 (47.18) 226 (46.79) 1.02 (0.77,1.35) 1.04 (0.78,1.38) 0.801
AA 82 (17.12) 82 (16.98) 1.02 (0.71,1.48) 0.99 (0.68,1.45) 0.967
GA/AA 308 (64.30) 308 (63.77) 1.02 (0.79,1.33) 1.03 (0.79,1.34) 0.844
Additive model    1.01 (0.85,1.21) 1.01 (0.84,1.21) 0.930
rs11536889 GG 303 (63.26) 293 (60.66) Reference Reference  
CG 156 (32.57) 166 (34.37) 0.91 (0.69,1.19) 0.91 (0.69,1.19) 0.477
CC 20 (4.18) 24 (4.97) 0.81 (0.44,1.49) 0.76 (0.40,1.43) 0.392
CG/CC 176 (36.74) 190 (39.34) 0.90 (0.69,1.16) 0.89 (0.69,1.16) 0.402
Additive model    0.90 (0.73,1.13) 0.90 (0.72,1.12) 0.355
TGF-BR1 rs6478974 TT 219 (45.72) 194 (40.17) Reference Reference  
AT 204 (42.59) 220 (45.55) 0.82 (0.63,1.08) 0.80 (0.61,1.06) 0.118
AA 56 (11.69) 69 (14.29) 0.72 (0.48,1.08) 0.68 (0.45,1.02) 0.063
AT/AA 260 (54.28) 289 (59.83) 0.80 (0.62,1.03) 0.78 (0.60,1.01) 0.055
Additive model    0.84 (0.70,1.01) 0.82 (0.68,0.99) 0.038
rs334348 AA 143 (29.85) 158 (32.71) Reference Reference  
AG 221 (46.14) 240 (49.69) 1.02 (0.76,1.36) 1.05 (0.78,1.42) 0.730
GG 115 (24.01) 85 (17.60) 1.50 (1.04,2.14) 1.51 (1.05,2.18) 0.028
AG/GG 336 (70.15) 325 (69.29) 1.14 (0.87,1.50) 1.17 (0.89,1.55) 0.263
Additive model    1.20 (1.01,1.43) 1.22 (1.02,1.46) 0.032
rs10512263 TT 279 (58.25) 262 (54.24) Reference Reference  
CT 178 (37.16) 187 (38.72) 0.89 (0.69,1.17) 0.87 (0.66,1.14) 0.297
CC 22 (4.59) 34 (7.04) 0.61 (0.35,1.07) 0.54 (0.31,0.97) 0.039
CT/CC 200 (41.75) 221 (45.76) 0.85 (0.66,1.10) 0.82 (0.63,1.06) 0.127
Additive model    0.84 (0.68,1.03) 0.81 (0.65,1.00) 0.047
  1. Italic represents any values with p < 0.05
  2. OR odds ratio
  3. aAdjusted for age, gender, smoking, drinking, and H. pylori infection status