Table 1 Association between polymorphisms and risk of gastric cancer
Polymorphism | Genotype | Cases, n (%) | Controls, n (%) | OR (95% CI) | OR (95% CI)a | p value |
|---|---|---|---|---|---|---|
IL-16 rs4072111 | CC | 334 (69.73) | 345 (71.43) | Reference | Reference | |
TC | 126 (26.30) | 122 (25.26) | 1.07 (0.80,1.43) | 1.01 (0.75,1.36) | 0.970 | |
TT | 19 (3.97) | 16 (3.31) | 1.23 (0.62,2.43) | 1.20 (0.60,2.41) | 0.600 | |
TC/TT | 145 (30.27) | 138 (28.57) | 1.09 (0.82,1.43) | 1.02 (0.77,1.36) | 0.870 | |
Additive model | 1.08 (0.86,1.37) | 1.04 (0.82,1.32) | 0.755 | |||
rs4778889 | TT | 267 (55.74) | 266 (55.07) | Reference | Reference | |
CT | 182 (38.00) | 192 (39.75) | 0.94 (0.73,1.23) | 0.92 (0.70,1.20) | 0.524 | |
CC | 30 (6.26) | 25 (5.18) | 1.20 (0.68,2.09) | 1.19 (0.68,2.10) | 0.542 | |
CT/CC | 212 (44.26) | 217 (44.93) | 0.97 (0.76,1.26) | 0.95 (0.73,0.23) | 0.688 | |
Additive model | 1.01 (0.82,1.25) | 1.00 (0.81,1.23) | 0.965 | |||
rs859 | TT | 129 (26.93) | 124 (25.67) | Reference | Reference | |
CT | 235 (49.06) | 248 (51.35) | 0.91 (0.67,1.24) | 0.88 (0.64,1.20) | 0.406 | |
CC | 115 (24.01) | 111 (22.98) | 1.00 (0.70,1.43) | 0.98 (0.68,1.41) | 0.899 | |
CT/CC | 350 (73.07) | 359 (74.33) | 0.94 (0.70,1.25) | 0.92 (0.68,1.23) | 0.551 | |
Additive model | 1.00 (0.83,1.19) | 0.98 (0.82,1.18) | 0.859 | |||
rs11556218 | TT | 306 (63.88) | 308 (63.77) | Reference | Reference | |
GT | 151 (31.52) | 157 (32.51) | 1.97 (0.74,1.27) | 0.93 (0.71,1.23) | 0.628 | |
GG | 22 (4.59) | 18 (3.73) | 1.23 (0.65,2.34) | 1.29 (0.68,2.48) | 0.439 | |
GT/GG | 173 (36.12) | 175 (36.23) | 1.00 (0.77,1.29) | 0.97 (0.94,1.27) | 0.820 | |
Additive model | 1.02 (0.82,1.28) | 1.01 (0.81,1.27) | 0.913 | |||
rs1131445 | TT | 221 (46.14) | 210 (43.48) | Reference | Reference | |
CT | 211 (44.05) | 222 (45.96) | 0.90 (0.69,1.18) | 0.94 (0.72,1.23) | 0.655 | |
CC | 47 (9.81) | 51 (10.56) | 0.88 (0.57,1.36) | 0.93 (0.59,1.46) | 0.748 | |
CT/CC | 258 (53.86) | 273 (56.52) | 0.90 (0.70,1.16) | 0.93 (0.72,1.21) | 0.592 | |
Additive model | 0.92 (0.76,1.12) | 0.95 (0.78,1.16) | 0.618 | |||
TLR4 rs10759932 | TT | 240 (50.10) | 251 (51.97) | Reference | Reference | |
TC | 191 (39.87) | 196 (40.58) | 1.02 (0.78,1.33) | 1.05 (0.80,1.38) | 0.733 | |
CC | 48 (10.02) | 36 (7.45) | 1.39 (0.87,2.22) | 1.38 (0.86,2.23) | 0.184 | |
TC/CC | 239 (49.90) | 232 (48.03) | 1.08 (0.84,1.39) | 1.10 (0.85,1.42) | 0.481 | |
Additive model | 1.11 (0.91,1.35) | 1.12 (0.92,1.36) | 0.275 | |||
rs1927911 | GG | 171 (35.70) | 175 (36.23) | Reference | Reference | |
GA | 226 (47.18) | 226 (46.79) | 1.02 (0.77,1.35) | 1.04 (0.78,1.38) | 0.801 | |
AA | 82 (17.12) | 82 (16.98) | 1.02 (0.71,1.48) | 0.99 (0.68,1.45) | 0.967 | |
GA/AA | 308 (64.30) | 308 (63.77) | 1.02 (0.79,1.33) | 1.03 (0.79,1.34) | 0.844 | |
Additive model | 1.01 (0.85,1.21) | 1.01 (0.84,1.21) | 0.930 | |||
rs11536889 | GG | 303 (63.26) | 293 (60.66) | Reference | Reference | |
CG | 156 (32.57) | 166 (34.37) | 0.91 (0.69,1.19) | 0.91 (0.69,1.19) | 0.477 | |
CC | 20 (4.18) | 24 (4.97) | 0.81 (0.44,1.49) | 0.76 (0.40,1.43) | 0.392 | |
CG/CC | 176 (36.74) | 190 (39.34) | 0.90 (0.69,1.16) | 0.89 (0.69,1.16) | 0.402 | |
Additive model | 0.90 (0.73,1.13) | 0.90 (0.72,1.12) | 0.355 | |||
TGF-BR1 rs6478974 | TT | 219 (45.72) | 194 (40.17) | Reference | Reference | |
AT | 204 (42.59) | 220 (45.55) | 0.82 (0.63,1.08) | 0.80 (0.61,1.06) | 0.118 | |
AA | 56 (11.69) | 69 (14.29) | 0.72 (0.48,1.08) | 0.68 (0.45,1.02) | 0.063 | |
AT/AA | 260 (54.28) | 289 (59.83) | 0.80 (0.62,1.03) | 0.78 (0.60,1.01) | 0.055 | |
Additive model | 0.84 (0.70,1.01) | 0.82 (0.68,0.99) | 0.038 | |||
rs334348 | AA | 143 (29.85) | 158 (32.71) | Reference | Reference | |
AG | 221 (46.14) | 240 (49.69) | 1.02 (0.76,1.36) | 1.05 (0.78,1.42) | 0.730 | |
GG | 115 (24.01) | 85 (17.60) | 1.50 (1.04,2.14) | 1.51 (1.05,2.18) | 0.028 | |
AG/GG | 336 (70.15) | 325 (69.29) | 1.14 (0.87,1.50) | 1.17 (0.89,1.55) | 0.263 | |
Additive model | 1.20 (1.01,1.43) | 1.22 (1.02,1.46) | 0.032 | |||
rs10512263 | TT | 279 (58.25) | 262 (54.24) | Reference | Reference | |
CT | 178 (37.16) | 187 (38.72) | 0.89 (0.69,1.17) | 0.87 (0.66,1.14) | 0.297 | |
CC | 22 (4.59) | 34 (7.04) | 0.61 (0.35,1.07) | 0.54 (0.31,0.97) | 0.039 | |
CT/CC | 200 (41.75) | 221 (45.76) | 0.85 (0.66,1.10) | 0.82 (0.63,1.06) | 0.127 | |
Additive model | 0.84 (0.68,1.03) | 0.81 (0.65,1.00) | 0.047 |