Table 2 Stratification analyses the association between polymorphisms in TGF-BR1 and gastric cancer risk
Genotype | Age | Gender | H. pylori infection | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
≤ 64 | > 64 | Male | Female | Positive | Negative | |||||||||||||
Ca/Co | OR (95% CI)a | p value | Ca/Co | OR (95% CI)a | p value | Ca/Co | OR (95% CI)a | p value | Ca/Co | OR (95% CI)a | p value | Ca/Co | OR (95% CI)a | p value | Ca/Co | OR (95% CI)a | p value | |
rs6478974 | ||||||||||||||||||
TT | 100/87 | Reference | 119/107 | Reference | 156/134 | Reference | 63/60 | Reference | 120/91 | Reference | 99/103 | Reference | ||||||
AT | 101/113 | 0.76 (0.51,1.13) | 0.175 | 103/107 | 0.85 (0.58,1.25) | 0.412 | 159/170 | 0.80 (0.58,1.10) | 0.164 | 45/50 | 0.81 (0.46,.41) | 0.452 | 108/107 | 0.76 (0.52,1.12) | 0.160 | 96/113 | 0.86 (0.58,1.28) | 0.457 |
AA | 28/30 | 0.76 (0.41,1.40) | 0.374 | 28/39 | 0.61 (0.34,1.07) | 0.082 | 38/54 | 0.55 (0.33,0.90) | 0.017 | 18/15 | 1.19 (0.55,2.58) | 0.663 | 33/33 | 0.73 (0.41,1.28) | 0.272 | 23/36 | 0.62 (0.34,1.14) | 0.127 |
AT/AA | 129/143 | 0.76 (0.52,1.11) | 0.156 | 131/146 | 0.80 (0.56,1.14) | 0.206 | 197/224 | 0.74 (0.54,1.00) | 0.049 | 63/65 | 0.89 (0.54,1.48) | 0.658 | 141/140 | 0.75 (0.52,1.08) | 0.125 | 119/149 | 0.81 (0.55,1.17) | 0.260 |
Additive model | 0.83 (0.63,1.10) | 0.199 | 0.81 (0.62,1.04) | 0.100 | 0.76 (0.61,0.95) | 0.016 | 1.01 (0.70,1.44) | 0.975 | 0.83 (0.64,1.08) | 0.157 | 0.81 (0.62,1.07) | 0.135 | ||||||
rs334348 | ||||||||||||||||||
AA | 72/74 | Reference | 71/84 | Reference | 108/121 | Reference | 35/37 | Reference | 77/83 | Reference | 66/75 | Reference | ||||||
AG | 105/122 | 0.95 (0.62,1.47) | 0.832 | 116/118 | 1.16 (0.77,1.76) | 0.478 | 168/173 | 1.15 (0.81,1.62) | 0.143 | 53/67 | 0.85 (0.46,1.54) | 0.583 | 124/100 | 1.43 (0.94,2.17) | 0.093 | 97/140 | 0.79 (0.51,1.21) | 0.278 |
GG | 52/34 | 1.57 (0.90,2.73) | 0.114 | 63/51 | 1.44 (0.88,2.37) | 0.146 | 77/64 | 1.37 (0.89,2.11) | 0.149 | 38/21 | 1.97 (0.94,4.11) | 0.072 | 60/48 | 0.37 (0.83,2.25) | 0.223 | 55/37 | 1.71 (0.99,2.53) | 0.054 |
AG/GG | 157/156 | 1.09 (0.72,1.63) | 0.694 | 179/169 | 1.26 (0.86,1.85) | 0.245 | 245/237 | 1.20 (0.87,1.66) | 0.269 | 91/88 | 1.10 (0.63,1.92) | 0.745 | 184/148 | 1.40 (0.95,2.06) | 0.088 | 152/177 | 0.98 (0.66,1.47) | 0.927 |
Additive model | 1.21 (0.93,1.59) | 0.161 | 1.22 (0.95,1.56) | 0.113 | 1.17 (0.95,1.45) | 0.141 | 1.36 (0.95,1.94) | 0.096 | 1.19 (0.93,1.53) | 0.166 | 1.25 (0.96,1.64) | 0.097 | ||||||
rs10512263 | ||||||||||||||||||
TT | 130/129 | Reference | 149/133 | Reference | 202/189 | Reference | 77/73 | Reference | 150/127 | Reference | 129/135 | Reference | ||||||
CT | 88/88 | 0.95 (0.64,1.41) | 0.814 | 90/99 | 0.80 (0.55,1.16) | 0.230 | 136/140 | 0.89 (0.65,1.22) | 0.470 | 42/47 | 0.82 (0.48,1.41) | 0.471 | 98/87 | 0.91 (0.62,1.33) | 0.610 | 80/100 | 0.83 (0.56,1.22) | 0.335 |
CC | 11/13 | 0.70 (0.29,1.67) | 0.417 | 11/21 | 0.44 (0.20,0.96) | 0.040 | 15/29 | 0.41 (0.21,0.81) | 0.010 | 7/5 | 1.40 (0.42,4.63) | 0.585 | 13/17 | 0.64 (0.29,1.39) | 0.258 | 9/17 | 0.45 (0.19,1.10) | 0.080 |
CT/CC | 99/101 | 0.91 (0.62,1.33) | 0.621 | 101/120 | 0.74 (0.52,1.06) | 0.101 | 151/169 | 0.80 (0.59,1.09) | 0.159 | 49/52 | 0.87 (0.52,1.46) | 0.604 | 111/104 | 0.86 (0.60,1.23) | 0.405 | 89/117 | 0.77 (0.53,1.13) | 0.180 |
Additive model | 0.88 (0.64,1.21) | 0.441 | 0.74 (0.55,0.99) | 0.040 | 0.76 (0.60,0.98) | 0.033 | 0.96 (0.63,1.48) | 0.864 | 0.85 (0.63,1.14) | 0.272 | 0.76 (0.56,1.04) | 0.083 | ||||||