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Table 3 Stratification analyses the association between polymorphisms in TGF-BR1 and gastric cancer by pathologic characteristics

From: Polymorphisms of TGFBR1, TLR4 are associated with prognosis of gastric cancer in a Chinese population

Genotype

Co

Clinical stage

Tumor site

T1–T2

T3–T4

Cardiac

Non-cardiac

Ca

OR (95% CI)a

p value

Ca

OR (95% CI)a

p value

Ca

OR (95% CI)a

p value

Ca

OR (95% CI)a

p value

rs6478974

 TT

194

75

Reference

 

144

Reference

 

62

Reference

 

157

Reference

 

 AT

220

69

0.82 (0.55,1.21)

0.311

135

0.79 (0.58,1.08)

0.140

62

0.87 (0.58,1.31)

0.497

142

0.78 (0.57,1.05)

0.105

 AA

69

15

0.54 (0.28,1.04)

0.065

41

0.76 (0.49,1.20)

0.238

14

0.61 (0.32,1.17)

0.139

42

0.72 (0.45,1.13)

0.147

 AT/AA

289

84

0.75 (0.52,1.09)

0.134

176

0.79 (0.59,1.05)

0.109

76

0.80 (0.54,1.18)

0.268

184

0.77 (0.58,1.02)

0.069

 Additive model

  

0.76 (0.57,1.01)

0.054

 

0.85 (0.69,1.05)

0.140

 

0.80 (0.60,1.07)

0.135

 

0.83 (0.67,1.02)

0.077

rs334348

 AA

158

45

Reference

 

98

Reference

 

40

Reference

 

103

Reference

 

 AG

240

73

1.19 (0.76,1.87)

0.442

148

1.01 (0.73,1.41)

0.937

64

1.14 (0.73,1.80)

0.565

157

1.04 (0.75,1.45)

0.825

 GG

85

41

1.73 (1.03,2.90)

0.039

74

1.42 (0.94,2.13)

0.092

34

1.56 (0.91,2.68)

0.103

81

1.48 (0.99,2.21)

0.055

 AG/GG

325

114

1.31 (0.87,1.99)

0.196

222

1.12 (0.82,1.52)

0.487

 

1.24 (0.81,1.89)

0.323

 

1.15 (0.85,1.57)

0.373

 Additive model

  

1.33 (1.02,1.73)

0.035

 

1.17 (0.96,1.43)

0.125

 

1.25 (0.95,1.64)

0.108

 

1.21 (0.99,1.47)

0.069

rs10512263

 TT

262

99

Reference

 

180

Reference

 

82

Reference

 

197

Reference

 

 CT

187

53

0.75 (0.51,1.12)

0.161

125

0.93 (0.69,1.25)

0.620

50

0.81 (0.54,1.21)

0.300

128

0.90 (0.67,1.21)

0.479

 CC

34

7

0.51 (0.21,1.24)

0.137

15

0.59 (0.31,1.13)

0.113

6

0.51 (0.20,1.28)

0.149

16

0.56 (0.29,1.07)

0.080

 CT/CC

221

60

0.71 (0.49,1.05)

0.084

140

0.88 (0.66,1.17)

0.366

56

0.76 (0.51,1.12)

0.162

144

0.85 (0.64,1.13)

0.256

 Additive model

  

0.73 (0.53,1.01)

0.054

 

0.85 (0.67,1.08)

0.184

 

0.76 (0.55,1.05)

0.093

 

0.83 (0.66,1.05)

0.120

  1. Italic represents any values with p < 0.05
  2. OR odds ratio, Ca case, Co control
  3. aAdjusted for age, gender, smoking, drinking, and H. pylori infection status
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Cancer Cell International

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