Skip to main content

Advertisement

Table 3 Stratification analyses the association between polymorphisms in TGF-BR1 and gastric cancer by pathologic characteristics

From: Polymorphisms of TGFBR1, TLR4 are associated with prognosis of gastric cancer in a Chinese population

Genotype Co Clinical stage Tumor site
T1–T2 T3–T4 Cardiac Non-cardiac
Ca OR (95% CI)a p value Ca OR (95% CI)a p value Ca OR (95% CI)a p value Ca OR (95% CI)a p value
rs6478974
 TT 194 75 Reference   144 Reference   62 Reference   157 Reference  
 AT 220 69 0.82 (0.55,1.21) 0.311 135 0.79 (0.58,1.08) 0.140 62 0.87 (0.58,1.31) 0.497 142 0.78 (0.57,1.05) 0.105
 AA 69 15 0.54 (0.28,1.04) 0.065 41 0.76 (0.49,1.20) 0.238 14 0.61 (0.32,1.17) 0.139 42 0.72 (0.45,1.13) 0.147
 AT/AA 289 84 0.75 (0.52,1.09) 0.134 176 0.79 (0.59,1.05) 0.109 76 0.80 (0.54,1.18) 0.268 184 0.77 (0.58,1.02) 0.069
 Additive model    0.76 (0.57,1.01) 0.054   0.85 (0.69,1.05) 0.140   0.80 (0.60,1.07) 0.135   0.83 (0.67,1.02) 0.077
rs334348
 AA 158 45 Reference   98 Reference   40 Reference   103 Reference  
 AG 240 73 1.19 (0.76,1.87) 0.442 148 1.01 (0.73,1.41) 0.937 64 1.14 (0.73,1.80) 0.565 157 1.04 (0.75,1.45) 0.825
 GG 85 41 1.73 (1.03,2.90) 0.039 74 1.42 (0.94,2.13) 0.092 34 1.56 (0.91,2.68) 0.103 81 1.48 (0.99,2.21) 0.055
 AG/GG 325 114 1.31 (0.87,1.99) 0.196 222 1.12 (0.82,1.52) 0.487   1.24 (0.81,1.89) 0.323   1.15 (0.85,1.57) 0.373
 Additive model    1.33 (1.02,1.73) 0.035   1.17 (0.96,1.43) 0.125   1.25 (0.95,1.64) 0.108   1.21 (0.99,1.47) 0.069
rs10512263
 TT 262 99 Reference   180 Reference   82 Reference   197 Reference  
 CT 187 53 0.75 (0.51,1.12) 0.161 125 0.93 (0.69,1.25) 0.620 50 0.81 (0.54,1.21) 0.300 128 0.90 (0.67,1.21) 0.479
 CC 34 7 0.51 (0.21,1.24) 0.137 15 0.59 (0.31,1.13) 0.113 6 0.51 (0.20,1.28) 0.149 16 0.56 (0.29,1.07) 0.080
 CT/CC 221 60 0.71 (0.49,1.05) 0.084 140 0.88 (0.66,1.17) 0.366 56 0.76 (0.51,1.12) 0.162 144 0.85 (0.64,1.13) 0.256
 Additive model    0.73 (0.53,1.01) 0.054   0.85 (0.67,1.08) 0.184   0.76 (0.55,1.05) 0.093   0.83 (0.66,1.05) 0.120
  1. Italic represents any values with p < 0.05
  2. OR odds ratio, Ca case, Co control
  3. aAdjusted for age, gender, smoking, drinking, and H. pylori infection status