TY - JOUR AU - Torre, L. A. AU - Bray, F. AU - Siegel, R. L. AU - Ferlay, J. AU - Lortet-Tieulent, J. AU - Jemal, A. PY - 2015 DA - 2015// TI - Global cancer statistics, 2012 JO - CA Cancer J Clin VL - 65 UR - https://doi.org/10.3322/caac.21262 DO - 10.3322/caac.21262 ID - Torre2015 ER - TY - JOUR AU - Molina, J. R. AU - Yang, P. AU - Cassivi, S. D. AU - Schild, S. E. AU - Adjei, A. A. PY - 2008 DA - 2008// TI - Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship JO - Mayo Clin Proc VL - 83 UR - https://doi.org/10.1016/S0025-6196(11)60735-0 DO - 10.1016/S0025-6196(11)60735-0 ID - Molina2008 ER - TY - JOUR AU - Herbst, R. S. AU - Morgensztern, D. AU - Boshoff, C. PY - 2018 DA - 2018// TI - The biology and management of non-small cell lung cancer JO - Nature VL - 553 ID - Herbst2018 ER - TY - JOUR AU - Goyeneche, A. A. AU - Telleria, C. M. PY - 2015 DA - 2015// TI - Antiprogestins in gynecological diseases JO - Reproduction VL - 149 UR - https://doi.org/10.1530/REP-14-0416 DO - 10.1530/REP-14-0416 ID - Goyeneche2015 ER - TY - JOUR AU - Grunberg, S. M. AU - Weiss, M. H. AU - Spitz, I. M. AU - Ahmadi, J. AU - Sadun, A. AU - Russell, C. A. AU - Lucci, L. AU - Stevenson, L. L. PY - 1991 DA - 1991// TI - Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone JO - J Neurosurg VL - 74 UR - https://doi.org/10.3171/jns.1991.74.6.0861 DO - 10.3171/jns.1991.74.6.0861 ID - Grunberg1991 ER - TY - JOUR AU - Li, D. Q. AU - Wang, Z. B. AU - Bai, J. AU - Zhao, J. AU - Wang, Y. AU - Hu, K. AU - Du, Y. H. PY - 2004 DA - 2004// TI - Effects of mifepristone on proliferation of human gastric adenocarcinoma cell line SGC-7901 in vitro JO - World J Gastroenterol VL - 10 UR - https://doi.org/10.3748/wjg.v10.i18.2628 DO - 10.3748/wjg.v10.i18.2628 ID - Li2004 ER - TY - JOUR AU - Gaddy, V. T. AU - Barrett, J. T. AU - Delk, J. N. AU - Kallab, A. M. AU - Porter, A. G. AU - Schoenlein, P. V. PY - 2004 DA - 2004// TI - Mifepristone induces growth arrest, caspase activation, and apoptosis of estrogen receptor-expressing, antiestrogen-resistant breast cancer cells JO - Clin Cancer Res VL - 10 UR - https://doi.org/10.1158/1078-0432.CCR-03-0637 DO - 10.1158/1078-0432.CCR-03-0637 ID - Gaddy2004 ER - TY - JOUR AU - Etreby, M. F. AU - Liang, Y. AU - Johnson, M. H. AU - Lewis, R. W. PY - 2000 DA - 2000// TI - Antitumor activity of mifepristone in the human LNCaP, LNCaP-C4, and LNCaP-C4-2 prostate cancer models in nude mice JO - Prostate VL - 42 UR - https://doi.org/3.0.CO;2-I DO - 3.0.CO;2-I ID - Etreby2000 ER - TY - JOUR AU - Rose, F. V. AU - Barnea, E. R. PY - 1996 DA - 1996// TI - Response of human ovarian carcinoma cell lines to antiprogestin mifepristone JO - Oncogene VL - 12 ID - Rose1996 ER - TY - JOUR AU - Stringer-Reasor, E. M. AU - Baker, G. M. AU - Skor, M. N. AU - Kocherginsky, M. AU - Lengyel, E. AU - Fleming, G. F. AU - Conzen, S. D. PY - 2015 DA - 2015// TI - Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma JO - Gynecol Oncol VL - 138 UR - https://doi.org/10.1016/j.ygyno.2015.06.033 DO - 10.1016/j.ygyno.2015.06.033 ID - Stringer-Reasor2015 ER - TY - JOUR AU - Goyeneche, A. A. AU - Caron, R. W. AU - Telleria, C. M. PY - 2007 DA - 2007// TI - Mifepristone inhibits ovarian cancer cell growth in vitro and in vivo JO - Clin Cancer Res VL - 13 UR - https://doi.org/10.1158/1078-0432.CCR-07-0164 DO - 10.1158/1078-0432.CCR-07-0164 ID - Goyeneche2007 ER - TY - JOUR AU - Gamarra-Luques, C. D. AU - Goyeneche, A. A. AU - Hapon, M. B. AU - Telleria, C. M. PY - 2012 DA - 2012// TI - Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin–paclitaxel therapy JO - BMC Cancer VL - 12 UR - https://doi.org/10.1186/1471-2407-12-200 DO - 10.1186/1471-2407-12-200 ID - Gamarra-Luques2012 ER - TY - JOUR AU - Freeburg, E. M. AU - Goyeneche, A. A. AU - Telleria, C. M. PY - 2009 DA - 2009// TI - Mifepristone abrogates repopulation of ovarian cancer cells in between courses of cisplatin treatment JO - Int J Oncol VL - 34 ID - Freeburg2009 ER - TY - JOUR AU - Zhang, L. AU - Hapon, M. B. AU - Goyeneche, A. A. AU - Srinivasan, R. AU - Gamarra-Luques, C. D. AU - Callegari, E. A. AU - Drappeau, D. D. AU - Terpstra, E. J. AU - Pan, B. AU - Knapp, J. R. PY - 2016 DA - 2016// TI - Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors JO - Mol Oncol VL - 10 UR - https://doi.org/10.1016/j.molonc.2016.05.001 DO - 10.1016/j.molonc.2016.05.001 ID - Zhang2016 ER - TY - JOUR AU - Freeburg, E. M. AU - Goyeneche, A. A. AU - Seidel, E. E. AU - Telleria, C. M. PY - 2009 DA - 2009// TI - Resistance to cisplatin does not affect sensitivity of human ovarian cancer cell lines to mifepristone cytotoxicity JO - Cancer Cell Int VL - 9 UR - https://doi.org/10.1186/1475-2867-9-4 DO - 10.1186/1475-2867-9-4 ID - Freeburg2009 ER - TY - JOUR AU - Gamarra-Luques, C. D. AU - Hapon, M. B. AU - Goyeneche, A. A. AU - Telleria, C. M. PY - 2014 DA - 2014// TI - Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity JO - J Ovarian Res VL - 7 UR - https://doi.org/10.1186/1757-2215-7-45 DO - 10.1186/1757-2215-7-45 ID - Gamarra-Luques2014 ER - TY - JOUR AU - Kim, J. J. AU - Tannock, I. F. PY - 2005 DA - 2005// TI - Repopulation of cancer cells during therapy: an important cause of treatment failure JO - Nat Rev Cancer VL - 5 UR - https://doi.org/10.1038/nrc1650 DO - 10.1038/nrc1650 ID - Kim2005 ER - TY - JOUR AU - Davis, A. J. AU - Tannock, J. F. PY - 2000 DA - 2000// TI - Repopulation of tumour cells between cycles of chemotherapy: a neglected factor JO - Lancet Oncol VL - 1 UR - https://doi.org/10.1016/S1470-2045(00)00019-X DO - 10.1016/S1470-2045(00)00019-X ID - Davis2000 ER - TY - JOUR AU - Brade, A. M. AU - Tannock, I. F. PY - 2006 DA - 2006// TI - Scheduling of radiation and chemotherapy for limited-stage small-cell lung cancer: repopulation as a cause of treatment failure? JO - J Clin Oncol VL - 24 UR - https://doi.org/10.1200/JCO.2005.04.9676 DO - 10.1200/JCO.2005.04.9676 ID - Brade2006 ER - TY - JOUR AU - Telleria, C. M. PY - 2013 DA - 2013// TI - Repopulation of ovarian cancer cells after chemotherapy JO - Cancer Growth Metastasis VL - 6 UR - https://doi.org/10.4137/CGM.S11333 DO - 10.4137/CGM.S11333 ID - Telleria2013 ER - TY - JOUR AU - Ng, W. L. AU - Huang, Q. AU - Liu, X. AU - Zimmerman, M. AU - Li, F. AU - Li, C. Y. PY - 2013 DA - 2013// TI - Molecular mechanisms involved in tumor repopulation after radiotherapy JO - Transl Cancer Res VL - 2 ID - Ng2013 ER - TY - JOUR AU - Goyeneche, A. A. AU - Seidel, E. E. AU - Telleria, C. M. PY - 2012 DA - 2012// TI - Growth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2 JO - Invest New Drugs VL - 30 UR - https://doi.org/10.1007/s10637-011-9655-z DO - 10.1007/s10637-011-9655-z ID - Goyeneche2012 ER - TY - JOUR AU - Jurado, R. AU - Lopez-Flores, A. AU - Alvarez, A. AU - Garcia-Lopez, P. PY - 2009 DA - 2009// TI - Cisplatin cytotoxicity is increased by mifepristone in cervical carcinoma: an in vitro and in vivo study JO - Oncol Rep VL - 22 ID - Jurado2009 ER - TY - JOUR AU - Chen, J. AU - Emara, N. AU - Solomides, C. AU - Parekh, H. AU - Simpkins, H. PY - 2010 DA - 2010// TI - Resistance to platinum-based chemotherapy in lung cancer cell lines JO - Cancer Chemother Pharmacol VL - 66 UR - https://doi.org/10.1007/s00280-010-1268-2 DO - 10.1007/s00280-010-1268-2 ID - Chen2010 ER - TY - JOUR AU - Sei, S. AU - Mussio, J. K. AU - Yang, Q. E. AU - Nagashima, K. AU - Parchment, R. E. AU - Coffey, M. C. AU - Shoemaker, R. H. AU - Tomaszewski, J. E. PY - 2009 DA - 2009// TI - Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells JO - Mol Cancer VL - 8 UR - https://doi.org/10.1186/1476-4598-8-47 DO - 10.1186/1476-4598-8-47 ID - Sei2009 ER - TY - JOUR AU - Ohtsu, T. AU - Sasaki, Y. AU - Tamura, T. AU - Miyata, Y. AU - Nakanomyo, H. AU - Nishiwaki, Y. AU - Saijo, N. PY - 1995 DA - 1995// TI - Clinical pharmacokinetics and pharmacodynamics of paclitaxel: a 3-hour infusion versus a 24-hour infusion JO - Clin Cancer Res VL - 1 ID - Ohtsu1995 ER - TY - JOUR AU - Rowinsky, E. K. AU - Jiroutek, M. AU - Bonomi, P. AU - Johnson, D. AU - Baker, S. D. PY - 1999 DA - 1999// TI - Paclitaxel steady-state plasma concentration as a determinant of disease outcome and toxicity in lung cancer patients treated with paclitaxel and cisplatin JO - Clin Cancer Res VL - 5 ID - Rowinsky1999 ER - TY - JOUR AU - Kurata, T. AU - Tamura, T. AU - Shinkai, T. AU - Ohe, Y. AU - Kunitoh, H. AU - Kodama, T. AU - Kakinuma, R. AU - Matsumoto, T. AU - Kubota, K. AU - Omatsu, H. PY - 2001 DA - 2001// TI - Phase I and pharmacological study of paclitaxel given over 3 h with cisplatin for advanced non-small cell lung cancer JO - Jpn J Clin Oncol VL - 31 UR - https://doi.org/10.1093/jjco/hye022 DO - 10.1093/jjco/hye022 ID - Kurata2001 ER - TY - JOUR AU - Urien, S. AU - Lokiec, F. PY - 2004 DA - 2004// TI - Population pharmacokinetics of total and unbound plasma cisplatin in adult patients JO - Br J Clin Pharmacol VL - 57 UR - https://doi.org/10.1111/j.1365-2125.2004.02082.x DO - 10.1111/j.1365-2125.2004.02082.x ID - Urien2004 ER - TY - JOUR AU - Im, A. AU - Appleman, L. J. PY - 2010 DA - 2010// TI - Mifepristone: pharmacology and clinical impact in reproductive medicine, endocrinology and oncology JO - Expert Opin Pharmacother VL - 11 UR - https://doi.org/10.1517/14656560903535880 DO - 10.1517/14656560903535880 ID - Im2010 ER - TY - JOUR AU - Check, J. H. AU - Check, D. AU - Wilson, C. AU - Lofberg, P. PY - 2016 DA - 2016// TI - Long-term high-quality survival with single-agent mifepristone treatment despite advanced cancer JO - Anticancer Res VL - 36 UR - https://doi.org/10.21873/anticanres.11251 DO - 10.21873/anticanres.11251 ID - Check2016 ER - TY - JOUR AU - Brandhagen, B. N. AU - Tieszen, C. R. AU - Ulmer, T. M. AU - Tracy, M. S. AU - Goyeneche, A. A. AU - Telleria, C. M. PY - 2013 DA - 2013// TI - Cytostasis and morphological changes induced by mifepristone in human metastatic cancer cells involve cytoskeletal filamentous actin reorganization and impairment of cell adhesion dynamics JO - BMC Cancer VL - 13 UR - https://doi.org/10.1186/1471-2407-13-35 DO - 10.1186/1471-2407-13-35 ID - Brandhagen2013 ER - TY - JOUR AU - Borm, B. AU - Requardt, R. P. AU - Herzog, V. AU - Kirfel, G. PY - 2005 DA - 2005// TI - Membrane ruffles in cell migration: indicators of inefficient lamellipodia adhesion and compartments of actin filament reorganization JO - Exp Cell Res VL - 302 UR - https://doi.org/10.1016/j.yexcr.2004.08.034 DO - 10.1016/j.yexcr.2004.08.034 ID - Borm2005 ER - TY - JOUR AU - Licun, W. AU - Tannock, I. F. PY - 2003 DA - 2003// TI - Selective estrogen receptor modulators as inhibitors of repopulation of human breast cancer cell lines after chemotherapy JO - Clin Cancer Res VL - 9 ID - Licun2003 ER - TY - JOUR AU - Wu, L. AU - Tannock, I. F. PY - 2005 DA - 2005// TI - Effect of the selective estrogen receptor modulator arzoxifene on repopulation of hormone-responsive breast cancer xenografts between courses of chemotherapy JO - Clin Cancer Res VL - 11 UR - https://doi.org/10.1158/1078-0432.CCR-05-1258 DO - 10.1158/1078-0432.CCR-05-1258 ID - Wu2005 ER - TY - JOUR AU - Wu, L. AU - Birle, D. C. AU - Tannock, I. F. PY - 2005 DA - 2005// TI - Effects of the mammalian target of rapamycin inhibitor CCI-779 used alone or with chemotherapy on human prostate cancer cells and xenografts JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-04-3137 DO - 10.1158/0008-5472.CAN-04-3137 ID - Wu2005 ER - TY - JOUR AU - Erenpreisa, J. AU - Cragg, M. S. PY - 2007 DA - 2007// TI - Cancer: a matter of life cycle? JO - Cell Biol Int VL - 31 UR - https://doi.org/10.1016/j.cellbi.2007.08.013 DO - 10.1016/j.cellbi.2007.08.013 ID - Erenpreisa2007 ER - TY - JOUR AU - Illidge, T. M. AU - Cragg, M. S. AU - Fringes, B. AU - Olive, P. AU - Erenpreisa, J. A. PY - 2000 DA - 2000// TI - Polyploid giant cells provide a survival mechanism for p53 mutant cells after DNA damage JO - Cell Biol Int VL - 24 UR - https://doi.org/10.1006/cbir.2000.0557 DO - 10.1006/cbir.2000.0557 ID - Illidge2000 ER - TY - JOUR AU - Sundaram, M. AU - Guernsey, D. L. AU - Rajaraman, M. M. AU - Rajaraman, R. PY - 2004 DA - 2004// TI - Neosis: a novel type of cell division in cancer JO - Cancer Biol Ther VL - 3 UR - https://doi.org/10.4161/cbt.3.2.663 DO - 10.4161/cbt.3.2.663 ID - Sundaram2004 ER - TY - JOUR AU - Puig, P. E. AU - Guilly, M. N. AU - Bouchot, A. AU - Droin, N. AU - Cathelin, D. AU - Bouyer, F. AU - Favier, L. AU - Ghiringhelli, F. AU - Kroemer, G. AU - Solary, E. PY - 2008 DA - 2008// TI - Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy JO - Cell Biol Int VL - 32 UR - https://doi.org/10.1016/j.cellbi.2008.04.021 DO - 10.1016/j.cellbi.2008.04.021 ID - Puig2008 ER - TY - JOUR AU - Coward, J. AU - Harding, A. PY - 2014 DA - 2014// TI - Size does matter: why polyploid tumor cells are critical drug targets in the war on cancer JO - Front Oncol VL - 4 UR - https://doi.org/10.3389/fonc.2014.00123 DO - 10.3389/fonc.2014.00123 ID - Coward2014 ER - TY - JOUR AU - Zhang, S. AU - Mercado-Uribe, I. AU - Xing, Z. AU - Sun, B. AU - Kuang, J. AU - Liu, J. PY - 2014 DA - 2014// TI - Generation of cancer stem-like cells through the formation of polyploid giant cancer cells JO - Oncogene VL - 33 UR - https://doi.org/10.1038/onc.2013.96 DO - 10.1038/onc.2013.96 ID - Zhang2014 ER - TY - JOUR AU - Duncan, A. W. AU - Taylor, M. H. AU - Hickey, R. D. AU - Hanlon Newell, A. E. AU - Lenzi, M. L. AU - Olson, S. B. AU - Finegold, M. J. AU - Grompe, M. PY - 2010 DA - 2010// TI - The ploidy conveyor of mature hepatocytes as a source of genetic variation JO - Nature VL - 467 UR - https://doi.org/10.1038/nature09414 DO - 10.1038/nature09414 ID - Duncan2010 ER - TY - JOUR AU - Dan, C. AU - Grygoryev, D. AU - Sandfort, K. AU - Connolly, M. AU - Cross, B. AU - Lasarev, M. AU - Kronenberg, A. AU - Turker, M. S. PY - 2011 DA - 2011// TI - Marked aneuploidy and loss of multiple chromosomes are common in autosomal mutants isolated from normal mouse kidney epithelium JO - Genes Chromosomes Cancer VL - 50 ID - Dan2011 ER - TY - JOUR AU - Orr-Weaver, T. L. PY - 2015 DA - 2015// TI - When bigger is better: the role of polyploidy in organogenesis JO - Trends Genet VL - 31 UR - https://doi.org/10.1016/j.tig.2015.03.011 DO - 10.1016/j.tig.2015.03.011 ID - Orr-Weaver2015 ER - TY - JOUR AU - Duncan, A. W. PY - 2013 DA - 2013// TI - Aneuploidy, polyploidy and ploidy reversal in the liver JO - Semin Cell Dev Biol VL - 24 UR - https://doi.org/10.1016/j.semcdb.2013.01.003 DO - 10.1016/j.semcdb.2013.01.003 ID - Duncan2013 ER - TY - JOUR AU - Huang, Q. AU - Li, F. AU - Liu, X. AU - Li, W. AU - Shi, W. AU - Liu, F. F. AU - O’Sullivan, B. AU - He, Z. AU - Peng, Y. AU - Tan, A. C. PY - 2011 DA - 2011// TI - Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy JO - Nat Med VL - 17 UR - https://doi.org/10.1038/nm.2385 DO - 10.1038/nm.2385 ID - Huang2011 ER - TY - JOUR AU - Cui, L. AU - Zhao, Y. AU - Pan, Y. AU - Zheng, X. AU - Shao, D. AU - Jia, Y. AU - He, K. AU - Li, K. AU - Chen, L. PY - 2017 DA - 2017// TI - Chemotherapy induces ovarian cancer cell repopulation through the caspase 3-mediated arachidonic acid metabolic pathway JO - Onco Targets Ther VL - 10 UR - https://doi.org/10.2147/OTT.S150456 DO - 10.2147/OTT.S150456 ID - Cui2017 ER - TY - JOUR AU - Cooke, S. L. AU - Ng, C. K. AU - Melnyk, N. AU - Garcia, M. J. AU - Hardcastle, T. AU - Temple, J. AU - Langdon, S. AU - Huntsman, D. AU - Brenton, J. D. PY - 2010 DA - 2010// TI - Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma JO - Oncogene VL - 29 UR - https://doi.org/10.1038/onc.2010.245 DO - 10.1038/onc.2010.245 ID - Cooke2010 ER - TY - JOUR AU - Grunberg, S. M. AU - Weiss, M. H. AU - Russell, C. A. AU - Spitz, I. M. AU - Ahmadi, J. AU - Sadun, A. AU - Sitruk-Ware, R. PY - 2006 DA - 2006// TI - Long-term administration of mifepristone (RU486): clinical tolerance during extended treatment of meningioma JO - Cancer Invest VL - 24 UR - https://doi.org/10.1080/07357900601062339 DO - 10.1080/07357900601062339 ID - Grunberg2006 ER -