TY - JOUR AU - Bing, Yike AU - Wund, Zacharie AU - Abratte, Tina AU - Borlle, Lucia AU - Kang, Susie AU - Southard, Teresa AU - Hume, Kelly R. PY - 2018 DA - 2018/11/22 TI - Biological indicators of chemoresistance: an ex vivo analysis of γH2AX and p53 expression in feline injection-site sarcomas JO - Cancer Cell International SP - 192 VL - 18 IS - 1 AB - The response of soft tissue sarcomas to cytotoxic chemotherapy is inconsistent. Biomarkers of chemoresistance or chemosensitivity are needed in order to identify appropriate patients for treatment. Given that many chemotherapeutics kill cells through direct DNA interactions, we hypothesized that upregulation of DNA damage response mechanisms would confer resistance to cytotoxic chemotherapy in sarcomas. To study this, we used spontaneously-occurring feline injection-site sarcomas (FISS). SN - 1475-2867 UR - https://doi.org/10.1186/s12935-018-0690-0 DO - 10.1186/s12935-018-0690-0 ID - Bing2018 ER -