ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2Q607R

Table 1 Characteristics of glioma patients in low and high ADAR3 expression group in CGGA dataset

Variable	Total (n = 309)	High ADAR3 expression (n = 154)	Low ADAR3 expression (n = 155)	P value
Age
< 45	178	104	74	0.0005
≥ 45	131	50	81
Gender
Male	115	57	58	1
Female	194	97	97
Grade
II	104	86	18	< 0.0001
III	67	35	32
IV	138	33	105
KPS
< 80	58	42	16	0.0006
≥ 80	108	46	62
NA	143	67	76
Subtype
Neural	76	71	5	< 0.0001
Proneural	99	61	38
Classical	69	14	55
Mesenchymal	65	8	57
IDH mutation
Mutant	155	108	47	< 0.0001
Wildtype	154	46	108
MGMT
Unmethylated	111	48	63	0.0462
Methylated	136	67	69
NA	62	39	23
1p/19q deletion
No	220	102	118	< 0.0001
Yes	36	31	5
NA	53	21	32
TERT
No	158	79	79	0.6426
Yes	91	43	48
NA	60	33	27

ISSN: 1475-2867