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Table 3 Clinic pathologic factors associated with OS in the Cox hazard regression analysis for LGG and GBM patients from the CGGA dataset

From: ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2Q607R

Variable Lower-grade glioma Glioblastoma
Univariate Multivariate Univariate Multivariate
P value HR 95% CI P value P value HR 95% CI P value
Gender 0.783     0.355    
Age at diagnosis < 0.001 1.023 0.992–1.054 0.143 0.569    
ADAR3 expression < 0.001 0.419 0.289–0.608 < 0.001 0.035 0.804 0.556–1.163 0.247
MGMT promoter methylation 0.225     0.010 0.551 0.342–0.886 0.014
IDH1/2 mutation status < 0.001 0.595 0.290–1.221 0.157 0.089    
Radiotherapy 0.056     < 0.001 0.447 0.273–0.733 0.001
Chemotherapy 0.002 1.397 0.705–2.770 0.338 < 0.001 0.441 0.271–0.717 < 0.001
  1. P value < 0.05 was considered statistically significant
  2. CI, confidence interval; HR, hazard ratio; IDH1/2, isocitrate dehydrogenase 1/2; MGMT, O6-methylguanine-DNA methyltransferase