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Table 3 Clinic pathologic factors associated with OS in the Cox hazard regression analysis for LGG and GBM patients from the CGGA dataset

From: ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2Q607R

Variable

Lower-grade glioma

Glioblastoma

Univariate

Multivariate

Univariate

Multivariate

P value

HR

95% CI

P value

P value

HR

95% CI

P value

Gender

0.783

   

0.355

   

Age at diagnosis

< 0.001

1.023

0.992–1.054

0.143

0.569

   

ADAR3 expression

< 0.001

0.419

0.289–0.608

< 0.001

0.035

0.804

0.556–1.163

0.247

MGMT promoter methylation

0.225

   

0.010

0.551

0.342–0.886

0.014

IDH1/2 mutation status

< 0.001

0.595

0.290–1.221

0.157

0.089

   

Radiotherapy

0.056

   

< 0.001

0.447

0.273–0.733

0.001

Chemotherapy

0.002

1.397

0.705–2.770

0.338

< 0.001

0.441

0.271–0.717

< 0.001

  1. P value < 0.05 was considered statistically significant
  2. CI, confidence interval; HR, hazard ratio; IDH1/2, isocitrate dehydrogenase 1/2; MGMT, O6-methylguanine-DNA methyltransferase
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Cancer Cell International

ISSN: 1475-2867

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