Fig. 5
From: miRNA-133b targets FGFR1 and presents multiple tumor suppressor activities in osteosarcoma
Elevating miR-133b or targeting FGFR1 suppressed Ras/MAPK and PI3K/Akt signaling pathways in OS cells. a The levels of FGFR1, p-PI3K, PI3K, p-Akt, Akt, Ras, Raf, p-Erk1/2, and Erk1/2 in MG-63 or U2OS cells transfected with miR-133b mimics vs. miR-133b NC, or with shFGFR1 vs. shNC were examined by Western blotting. b–f The quantification of p-PI3K, p-Akt, Ras, Raf, and p-Erk1/2 from indicated samples, respectively. *P < 0.05, **P < 0.01 and ***P < 0.001