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Fig. 1 | Cancer Cell International

Fig. 1

From: Cellular and clinicopathological features of the IL-33/ST2 axis in human esophageal squamous cell carcinomas

Fig. 1

Immunohistochemical (IHC) examination of IL-33 and its functional receptor ST2 in the ESSC microenvironment. In the lamina propria of control esophageal tissues, IL-33-immunoreactivity (IR) was observed in squamous epithelium particularly in the deep layer (black arrow in A) and stromal cells (black arrowhead in A). In the stroma of ESCCs, IL-33-IR was observed in both ESCC cells (black arrow in B) and stromal cells (black arrowhead in B). Similarly, intensive ST2-IR was frequently observed in the ESCC cells (black arrow in E) and stroma cells (arrowhead in E) as compared with control sections (D). Both IL-33-IR and ST2-IR were not shown in isotopy-matched negative controls (C, F). (A–F: IHC, counterstained with hematoxylin, original magnification ×400)

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