Table 1 Characteristics of studies included in the meta-analysis
From: Prognostic significance of CXCR7 in cancer patients: a meta-analysis
Author | Year | Region | Type of cancer | Sample size (high/low) | Follow-up (month) | Endpoints | Expression associated with poor prognosis | Assay method | Cut-off value | Survival analysis | NOS score | Method |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Salazar et al. [31] | 2018 | USA | Glioma | 77 | 113 | OS | High | mRNA microarray data | Median | NA | 6 | 1 |
49 | 80 | OS | High | mRNA microarray data | Median | NA | 6 | 1 | ||||
Werner et al. [34] | 2018 | Germany | Thyroid carcinoma | 25/15 | 197 | OS, RFS | High | Tissue microarray IHC | Median | Univariate multivariate | 8 | 1 |
Qiao et al. [35] | 2018 | China | Esophageal squamous cell carcinoma | 23/22 | 40 | OS, PFS | High | IHC, RT-PCR | Median | NA | 7 | 2 |
Hao et al. [39] | 2018 | China | Breast cancer | 593 | 200 | RFS | High | cDNA-array | NA | NA | 6 | 1 |
Chang et al. [26] | 2017 | China | Extramammary paget disease | 21/71 | 130 | DFS | High | IHC | High: the product of intensity score and quantity score was 4–9 | Univariate and multivariate | 8 | 1 |
D’Alterio et al. [10] | 2010 | Italy | Renal cancer | 100/70 | 180 | DFS | High | IHC | High: stained (positive) tumor cells in 10 high power field (400×)/slide: > 20%. | Univariate and multivariate | 8 | 1 |
Hui et al. [48] | 2016 | China | Oral squamous cell carcinoma | 66 | 60 | OS | High | IHC | NA | NA | 6 | 2 |
Wani et al. [41] | 2014 | USA | Breast cancer | 85/440 | 220 | OS | High | RNA array datasets | High: ACKR3 (CXCR7 gene symbol) is greater than 1.0-fold of the standard deviation above the mean | NA | 6 | 2 |
Polimeno et al. [42] | 2015 | Italy | Hepatocellular carcinoma | 74/6 | 126 | OS | NS | IHC | High: stained (positive) tumor cells > 60% | Univariate | 7 | 1 |
11/28 | 87 | OS | NS | IHC | High: stained (positive) tumor cells > 60% | Univariate | 7 | 1 | ||||
D’Alterio et al. [24] | 2016 | Italy | Colorectal cancer | 14/16 | 66 | PFS | High | IHC | High: the rate of stained cancer cells was more than 50% | Univariate | 7 | 1 |
Tachezy et al. [36] | 2013 | Germany | Esophageal cancer | 72/87 | 178 | OS | NS | IHC | High: spots with staining intensity ≥ 2 were classified as CXCR7 positive | NA | 6 | 2 |
D’Alterio et al. [52] | 2014 | Italy | Rectal cancer | 43/21 | 127 | RFS | NS | IHC | High: the percentage of the total number of stained cells > 50% | Univariate | 7 | 1 |
Deng et al. [32] | 2017 | China | Glioblastoma | 77/69 | 43 | OS | High | IHC | High: the staining intensity score of CXCR7 > 1 | Univariate and multivariate | 7 | 1 |
Franco et al. [44] | 2012 | Italy | Non-small cell lung cancer | 19/26 | 26 | OS | High | IHC | High: the percentage of the total number of stained cells > 30% | Univariate and multivariate | 7 | 2 |
Gebauer et al. [46] | 2011 | Germany | Pancreatic adenocarcinoma | 47/202 | 175 | OS | NS | IHC | High: the percentage of the total number of stained cells > 20% | Multivariate | 7 | 2 |
Goto et al. [37] | 2017 | Japan | Esophageal squamous cell carcinoma | 40/73 | 97 | RFS | NS | IHC | High: the expression grades in cytoplasm ≥ 1 | Univariate and multivariate | 7 | 2 |
Guo et al. [23] | 2016 | China | Pancreatic cancer | 66/116 | 87 | OS | High | IHC | High: the multiplication of positive cell proportion score and staining score was 4–9 | Univariate and multivariate | 7 | 1 |
53/100 | 95 | OS | High | IHC | High: the multiplication of positive cell proportion score and staining score was 4–9 | Univariate and multivariate | 7 | 1 | ||||
Wang et al. [47] | 2012 | China | Renal cell carcinoma | 72/25 | 120 | OS, RFS | High | IHC | High: the percentage of the total number of stained cells ≥ 30% | Univariate and multivariate | 8 | 1 |
Iwakiri et al. [45] | 2009 | Japan | Nonsmall cell lung cancer | 44/35 | 66 | DFS, OS | High | RT-PCR | Median | Multivariate | 7 | 1 |
Li et al. [49] | 2015 | China | Chondrosarcoma | 49/11 | 65 | OS | High | IHC | High: the percentage of the total number of stained cells ≥ 10% | NA | 7 | 2 |
Liu et al. [33] | 2015 | USA | Glioma | 144/199 | 120 | OS | High | Microarray | High: fourfold elevated expression of CXCR7 | NA | 6 | 2 |
Ribas et al. [40] | 2014 | UK | Breast cancer | 125/375 | 144 | RFS | High | IHC | The highest quartile of the gene expression was used to dichotomise the patients into high and low groups (> 75%) | NA | 7 | 2 |
209/631 | 144 | RFS | High | IHC | The highest quartile of the gene expression was used to dichotomise the patients into high and low groups (> 75%) | NA | 7 | 2 | ||||
Nambara et al. [57] | 2016 | Singapore | Gastric Cancer | 98/98 | 60 | OS | High | RT-PCR | Median | NA | 7 | 2 |
Japan | Gastric Cancer | 98/97 | 60 | OS | High | RT-PCR | Median | NA | 7 | 2 | ||
Schrevel et al. [54] | 2012 | Netherlands | Cervical cancer | 43/58 | 266 | DFS | High | IHC | High: immunoreactivity was scored as weak, moderate or strong staining intensity | Univariate and multivariate | 8 | 1 |
Wu et al. [38] | 2015 | China | Breast cancer | 57/58 | 89 | OS | High | RT-PCR | Median | Univariate and multivariate | 7 | 1 |
Xue et al. [43] | 2014 | China | Hepatocellular carcinoma | 40/34 | 110 | OS, RFS | High | IHC | High: the percentage of tumor cells ≥ 80% (in 2+ intensity cells) or ≥ 30% (in 3+ intensity cells) were considered high | NA | 7 | 2 |
Yang et al. [51] | 2015 | China | Colorectal carcinoma | 62/34 | 60 | OS, PFS | High | IHC | High: the multiplication of positive cell proportion score and staining score ≥ 2 | Univariate and multivariate | 7 | 1 |
Yao et al. [53] | 2011 | China | Gallbladder cancer | 49/23 | 95 | OS | High | IHC | High: the multiplication of positive cell proportion score and staining score ≥ 2 | Univariate and multivariate | 7 | 1 |