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Fig. 7 | Cancer Cell International

Fig. 7

From: Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species

Fig. 7

Gambogic acid (GA) and chloroquine (CQ) act synergistically against a pancreatic cancer xenograft tumor model. Xenograft tumor model was created with BxPC-3 cells in nude mice. a Xenograft tumors of four groups. b Tumor volume of four groups was measured every 3 days. * indicates the CQ + GA group compared to the GA group, P < 0.05; # indicates the GA group compared to the CQ group, P < 0.05. c Tumor weight. d Immunohistochemical (IHC) analysis of LC3-II, Ki-67, and TUNEL in xenograft tumor specimens. Scale bars indicate 200 µm. e Quantification of IHC staining of LC3-II, Ki-67, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL). Data are presented as mean ± SD (n = 5), * indicates P < 0.05; ** indicates P < 0.01; *** indicates P < 0.001

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