Fig. 1
From: Expression signatures and roles of microRNAs in inflammatory breast cancer
Schema of miR-301 regulated pathways. A proposed model wherein miR-301 overexpression in human breast cancer can downregulate several mRNA targets, including Col2A1, PTEN, FoxF2, and BBC3. In turn, downregulation of Col2A1 can lead to increased migration and invasion. Similarly, PTEN downregulation will lead to Akt activation, which can promote VEGF expression, with increased tumor angiogenesis. Downregulation of FoxF2 can increase expression of Wnt5a, which can promote cell proliferation. In parallel, SKA2 is also co-expressed with miR-301, which can also potentially increase proliferation [40]