Fig. 2From: Expression signatures and roles of microRNAs in inflammatory breast cancerSchema of miR-451 regulated YWHAZ pathway. miR-451 markedly inhibited expression of β-catenin via YWHAZ and subsequently inhibited downstream gene cyclin D1, c-Myc expression, which leads to paclitaxel resistance. Thus, downregulation of miR-451 is able to upregulate YWHAZ expression so that may reduce paclitaxel resistance in IBC [41]Back to article page