Fig. 4From: Expression signatures and roles of microRNAs in inflammatory breast cancerSchema of miR-19a-3p regulated Fra-1 gene pathway. miR-19a-3p, which regulates TAMs in the breast tumor microenvironment, is able to regulate the phenotype of TAMs by targeting the Fra-1 gene and other genes in its downstream signaling pathway. IL-6 activates M2 polarization-related signal pathways of TAMs by inhibiting miR-19a-3p expression. The downregulation of miR-19a-3p expression in TAMs is likely due to TME induction, which promotes transformation of M1 to M2 and results in the enhancement of migration and invasion of breast cancer cellsBack to article page