Fig. 5

Schema of miR-7 regulated EGFR, IGF1R and Wave3 pathway. miR-7 is expressed at a low level in highly invasive cells, and when added as a form of mimic, it appears to play a more potent role in inhibition of invasive breast cancer cell migration. More importantly, miR-7 mimic indeed has a dual effect as it also significantly inhibits the proliferative, chemotactic and angiogenic-like homing characteristics of endothelial cells especially in response to o chemoattractant factors produced by aggressive breast cancer cells, also suggesting that miR-7 may be developed as an anti-cancer therapeutic potentially capable of suppressing breast cancer metastasis and tumour-associated angiogenesis simultaneously [52]