Fig. 6
From: Expression signatures and roles of microRNAs in inflammatory breast cancer
Schema of miR-21 regulated PTEN, PDCD4, SPRY2 pathway. Schematic diagram representing the mechanism of LPA-induced early steps of metastasis formation. Acting on LPA1 receptor LPA activates PI3K/AKT inducing ZEB1 expression and down-stream activation of miR-21 that by inhibiting the expression of anti-metastatic genes (PTEN, PDCD4, SPRY2) induces cell migration, invasion and metastasis dissemination