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Table 3 Results of univariate log-rank analysis of prognostic factors for overall survival and disease-free survival in 169 patients with ESCC receiving esophagectomy

From: An actin-binding protein ESPN is an independent prognosticator and regulates cell growth for esophageal squamous cell carcinoma

Factors No. of patients Overall survival (OS) Disease-free survival (DFS)
5-year OS rate (%) P value 5-year DFS rate (%) P value
Age
 < 55 y/o 83 48 0.35 43 0.15
 ≥ 55 y/o 86 36   29  
Location
 U/M 90 43 0.98 37 0.70
 L 79 41   36  
Pathological T classification
 T1/2 90 58 < 0.001* 48 < 0.001*
 T3/4 79 24   23  
Pathological N classification
 N0 115 53 < 0.001* 45 < 0.001*
 N1/2/3 54 19   17  
Pathological 7th AJCC stage
 I/II 123 52 < 0.001* 44 < 0.001*
 III 46 15   15  
Histological grading
 Grade 1/2 125 46 0.088 38 0.18
 Grade 3 44 32   30  
Surgical margin
 Negative 150 45 0.01* 38 0.02*
 Positive 19 21   21  
ESPN expression
 Low expression 83 54 0.005* 43 0.035*
 High expression 86 30   29  
  1. AJCC American Joint Committee on Cancer
  2. * Statistically significant