TY - STD TI - Cancer in South Africa 2014. South African Natl. Cancer Regist. 2018. http://www.nicd.ac.za/index.php/centres/national-cancer-registry/cancer-statistics/. UR - http://www.nicd.ac.za/index.php/centres/national-cancer-registry/cancer-statistics/ ID - ref1 ER - TY - STD TI - Jin L, Han B, Siegel E, Cui Y, Giuliano A, Cui X. Breast cancer lung metastasis: molecular biology and therapeutic implications. Cancer Biol Ther. 2018:1–11. http://www.tandfonline.com/action/journalInformation?journalCode=kcbt20. UR - http://www.tandfonline.com/action/journalInformation?journalCode=kcbt20 ID - ref2 ER - TY - JOUR AU - Seguin, L. AU - Desgrosellier, J. S. AU - Weis, S. M. AU - Cheresh, D. A. PY - 2015 DA - 2015// TI - Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance JO - Trends Cell Biol VL - 25 UR - https://doi.org/10.1016/j.tcb.2014.12.006 DO - 10.1016/j.tcb.2014.12.006 ID - Seguin2015 ER - TY - JOUR AU - Wennerberg, K. AU - Armulik, A. AU - Sakai, T. AU - Karlsson, M. AU - Fässler, R. AU - Schaefer, E. M. PY - 2000 DA - 2000// TI - The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation JO - Mol Cell Biol. VL - 20 UR - https://doi.org/10.1128/MCB.20.15.5758-5765.2000 DO - 10.1128/MCB.20.15.5758-5765.2000 ID - Wennerberg2000 ER - TY - JOUR AU - Huveneers, S. AU - Bout, I. AU - Sonneveld, P. AU - Sancho, A. AU - Sonnenberg, A. AU - Danen, E. H. J. PY - 2007 DA - 2007// TI - Integrin alpha v beta 3 controls activity and oncogenic potential of primed c-Src JO - Cancer Res VL - 67 UR - https://doi.org/10.1158/0008-5472.CAN-06-3654 DO - 10.1158/0008-5472.CAN-06-3654 ID - Huveneers2007 ER - TY - JOUR AU - Wozniak, M. A. AU - Modzelewska, K. AU - Kwong, L. AU - Keely, P. J. PY - 2004 DA - 2004// TI - Focal adhesion regulation of cell behavior JO - Biochim Biophys Acta Mol Cell Res. VL - 1692 UR - https://doi.org/10.1016/j.bbamcr.2004.04.007 DO - 10.1016/j.bbamcr.2004.04.007 ID - Wozniak2004 ER - TY - JOUR AU - Etienne-manneville, S. PY - 2013 DA - 2013// TI - Microtubules in cell migration JO - Annu Rev Cell Dev Biol VL - 29 UR - https://doi.org/10.1146/annurev-cellbio-101011-155711 DO - 10.1146/annurev-cellbio-101011-155711 ID - Etienne-manneville2013 ER - TY - JOUR AU - Stehbens, S. AU - Wittmann, T. PY - 2012 DA - 2012// TI - Targeting and transport: how microtubules control focal adhesion dynamics JO - J Cell Biol VL - 198 UR - https://doi.org/10.1083/jcb.201206050 DO - 10.1083/jcb.201206050 ID - Stehbens2012 ER - TY - JOUR AU - Kaverina, I. AU - Rottner, K. AU - Small, J. V. PY - 1998 DA - 1998// TI - Targeting, capture, and stabilization of microtubules at early focal adhesions JO - J Cell Biol VL - 142 UR - https://doi.org/10.1083/jcb.142.1.181 DO - 10.1083/jcb.142.1.181 ID - Kaverina1998 ER - TY - JOUR AU - Rid, R. AU - Schiefermeier, N. AU - Grigoriev, I. AU - Small, J. V. AU - Kaverina, I. PY - 2005 DA - 2005// TI - The last but not the least: the origin and significance of trailing adhesions in fibroblastic cells JO - Cell Motil Cytoskeleton. VL - 61 UR - https://doi.org/10.1002/cm.20076 DO - 10.1002/cm.20076 ID - Rid2005 ER - TY - JOUR AU - Kaverina, I. AU - Krylyshkina, O. AU - Small, J. V. PY - 1999 DA - 1999// TI - Microtubule targeting of substrate contacts promotes their relaxation and dissociation JO - J Cell Biol VL - 146 UR - https://doi.org/10.1083/jcb.146.5.1033 DO - 10.1083/jcb.146.5.1033 ID - Kaverina1999 ER - TY - JOUR AU - Hamel, E. AU - Lin, C. M. AU - Flynn, E. AU - D’Amato, R. J. PY - 1996 DA - 1996// TI - Interactions of 2-methoxyestradiol, an endogenous mammalian metabolite, with unpolymerized tubulin and with tubulin polymers JO - Biochemistry VL - 35 UR - https://doi.org/10.1021/bi951559s DO - 10.1021/bi951559s ID - Hamel1996 ER - TY - JOUR AU - D’Amato, R. J. AU - Lin, C. M. AU - Flynn, E. AU - Folkman, J. AU - Hamel, E. PY - 1994 DA - 1994// TI - 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site JO - Proc Natl Acad Sci USA VL - 91 UR - https://doi.org/10.1073/pnas.91.9.3964 DO - 10.1073/pnas.91.9.3964 ID - D’Amato1994 ER - TY - JOUR AU - Mabjeesh, N. J. AU - Escuin, D. AU - LaVallee, T. M. AU - Pribluda, V. S. AU - Swartz, G. M. AU - Johnson, M. S. PY - 2003 DA - 2003// TI - 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF JO - Cancer Cell VL - 3 UR - https://doi.org/10.1016/S1535-6108(03)00077-1 DO - 10.1016/S1535-6108(03)00077-1 ID - Mabjeesh2003 ER - TY - JOUR AU - Lambert, C. AU - Apel, K. AU - Biesalski, H. K. AU - Frank, J. PY - 2004 DA - 2004// TI - 2-Methoxyestradiol induces caspase-independent, mitochondria-centered apoptosis in DS-sarcoma cells JO - Int J Cancer VL - 108 UR - https://doi.org/10.1002/ijc.11579 DO - 10.1002/ijc.11579 ID - Lambert2004 ER - TY - STD TI - Yue T-L, Wang X, Louden CS, Gupta S, Pillarisetti K, Gu J-L, et al. 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and fas expression. Mol Pharmacol. 1997;51:951–62. http://molpharm.aspetjournals.org/content/51/6/951.long. UR - http://molpharm.aspetjournals.org/content/51/6/951.long ID - ref16 ER - TY - JOUR AU - Ireson, C. R. AU - Chander, S. K. AU - Purohit, A. AU - Perera, S. AU - Newman, S. P. AU - Parish, D. PY - 2004 DA - 2004// TI - Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents JO - Br J Cancer. VL - 90 UR - https://doi.org/10.1038/sj.bjc.6601591 DO - 10.1038/sj.bjc.6601591 ID - Ireson2004 ER - TY - JOUR AU - Tevaarwerk, A. J. AU - Holen, K. D. AU - Alberti, D. B. AU - Sidor, C. AU - Arnott, J. AU - Quon, C. PY - 2009 DA - 2009// TI - Phase I trial of 2-methoxyestradiol NanoCrystal dispersion in advanced solid malignancies JO - Clin Cancer Res VL - 15 UR - https://doi.org/10.1158/1078-0432.CCR-08-1599 DO - 10.1158/1078-0432.CCR-08-1599 ID - Tevaarwerk2009 ER - TY - JOUR AU - Stander, A. AU - Joubert, F. AU - Joubert, A. PY - 2011 DA - 2011// TI - Docking, synthesis, and in vitro evaluation of antimitotic estrone analogs JO - Chem Biol Drug Des VL - 77 UR - https://doi.org/10.1111/j.1747-0285.2010.01064.x DO - 10.1111/j.1747-0285.2010.01064.x ID - Stander2011 ER - TY - JOUR AU - Theron, A. AU - Prudent, R. AU - Nolte, E. AU - Bout, I. AU - Punchoo, R. AU - Marais, S. PY - 2015 DA - 2015// TI - Novel in silico-designed estradiol analogues are cytotoxic to a multidrug-resistant cell line at nanomolar concentrations JO - Cancer Chemother Pharmacol VL - 75 UR - https://doi.org/10.1007/s00280-014-2653-z DO - 10.1007/s00280-014-2653-z ID - Theron2015 ER - TY - JOUR AU - Stander, B. A. AU - Joubert, F. AU - Tu, C. AU - Sippel, K. H. AU - McKenna, R. AU - Joubert, A. M. PY - 2012 DA - 2012// TI - In vitro evaluation of ESE-15-ol, an estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity JO - PLoS ONE VL - 7 UR - https://doi.org/10.1371/journal.pone.0052205 DO - 10.1371/journal.pone.0052205 ID - Stander2012 ER - TY - JOUR AU - Whitfield, M. L. AU - Sherlock, G. AU - Saldanha, A. J. AU - Murray, J. I. AU - Ball, C. A. AU - Alexander, K. E. PY - 2002 DA - 2002// TI - Identification of genes periodically expressed in the human cell cycle and their expression in tumors JO - Mol Biol Cell. VL - 13 UR - https://doi.org/10.1091/mbc.02-02-0030 DO - 10.1091/mbc.02-02-0030 ID - Whitfield2002 ER - TY - JOUR AU - Dahut, W. L. AU - Lakhani, N. J. AU - Gulley, J. L. AU - Arlen, P. M. AU - Kohn, E. C. AU - Kotz, H. PY - 2006 DA - 2006// TI - Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors JO - Cancer Biol Ther VL - 5 UR - https://doi.org/10.4161/cbt.5.1.2349 DO - 10.4161/cbt.5.1.2349 ID - Dahut2006 ER - TY - JOUR AU - Visagie, M. H. AU - Mqoco, T. V. AU - Joubert, A. M. PY - 2012 DA - 2012// TI - Sulphamoylated estradiol analogue induces antiproliferative activity and apoptosis in breast cell lines JO - Cell Mol Biol Lett VL - 17 UR - https://doi.org/10.2478/s11658-012-0030-7 DO - 10.2478/s11658-012-0030-7 ID - Visagie2012 ER - TY - JOUR AU - Visagie, M. H. AU - Birkholtz, L. AU - Joubert, A. M. PY - 2014 DA - 2014// TI - 17-Beta-estradiol analog inhibits cell proliferation by induction of apoptosis in breast cell lines JO - Microscopy Res Tech VL - 242 UR - https://doi.org/10.1002/jemt.22334 DO - 10.1002/jemt.22334 ID - Visagie2014 ER - TY - BOOK AU - Eke, I. AU - Cordes, N. PY - 2014 DA - 2014// TI - Focal adhesion signaling and therapy resistance in cancer PB - Elsevier Ltd CY - New York ID - Eke2014 ER - TY - JOUR AU - Krendel, M. AU - Zenke, F. T. AU - Bokoch, G. M. PY - 2002 DA - 2002// TI - Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton JO - Nat Cell Biol VL - 4 UR - https://doi.org/10.1038/ncb773 DO - 10.1038/ncb773 ID - Krendel2002 ER - TY - JOUR AU - Yang, H. AU - Ganguly, A. AU - Cabral, F. PY - 2010 DA - 2010// TI - Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs JO - J Biol Chem VL - 285 UR - https://doi.org/10.1074/jbc.M110.160820 DO - 10.1074/jbc.M110.160820 ID - Yang2010 ER - TY - JOUR AU - Villari, G. AU - Jayo, A. AU - Zanet, J. AU - Fitch, B. AU - Serrels, B. AU - Frame, M. PY - 2015 DA - 2015// TI - A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration JO - J Cell Sci. VL - 128 UR - https://doi.org/10.1242/jcs.175760 DO - 10.1242/jcs.175760 ID - Villari2015 ER - TY - JOUR AU - Nalbant, P. AU - Chang, Y. -. C. AU - Birkenfeld, J. AU - Chang, Z. -. F. AU - Bokoch, G. M. PY - 2009 DA - 2009// TI - Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge JO - Mol Biol Cell. VL - 20 UR - https://doi.org/10.1091/mbc.e09-01-0041 DO - 10.1091/mbc.e09-01-0041 ID - Nalbant2009 ER -