T cell receptor-engineered T cells for leukemia immunotherapy

Table 1 Researches about leukemia-specific TCRs

Leukemia-specific TCRs	T cell type	HLA restriction	Leukemia	Research references
WT1-TCRs	CD4⁺ T cells CD8⁺ T cells	HLA-A2 HLA-DPB105:01 HLA-A2402⁺	AML, CML, MDS	[14,15,16,17,18,19]
FMNL1-TCRs	CD4⁺ T cells	HLA-DRB10101 HLADRB11101	AML, lymphoma, myeloma	[20]
TERT-TCRs	CD34⁺ cells PBMC CD8⁺ T cells	HLA-A0201 HLA-A24:02 HLA-A2	B-CLL, ATL, AML, B-ALL	[4, 21, 22]
AURKA-TCRs	CD8⁺ T cells	HLA-A*0201	T-ALL, ATL	[23, 24]
MDM2-TCRs	CD4⁺ T cells CD8⁺ T cells	HLA-A*0201	AML, T lymphocytes	[25, 26]
BOB1-TCRs	PBMC CD4⁺ T cells CD8⁺ T cells	HLA-B*07:02	Lymphocytic B-cell, CLL, ALL, mantle cell lymphoma, MM	[27]
HMMR/Rhamn-TCRs	CD8⁺ T cells	CD8⁺ T cells	AML	[28]

ISSN: 1475-2867