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Table 1 Researches about leukemia-specific TCRs

From: T cell receptor-engineered T cells for leukemia immunotherapy

Leukemia-specific TCRs T cell type HLA restriction Leukemia Research references
WT1-TCRs CD4+ T cells
CD8+ T cells
HLA-A2
HLA-DPB1*05:01
HLA-A*2402+
AML, CML, MDS [14,15,16,17,18,19]
FMNL1-TCRs CD4+ T cells HLA-DRB1*0101 HLADRB1*1101 AML, lymphoma, myeloma [20]
TERT-TCRs CD34+ cells
PBMC
CD8+ T cells
HLA-A*0201
HLA-A*24:02
HLA-A2
B-CLL, ATL, AML, B-ALL [4, 21, 22]
AURKA-TCRs CD8+ T cells HLA-A*0201 T-ALL, ATL [23, 24]
MDM2-TCRs CD4+ T cells
CD8+ T cells
HLA-A*0201 AML, T lymphocytes [25, 26]
BOB1-TCRs PBMC
CD4+ T cells
CD8+ T cells
HLA-B*07:02 Lymphocytic B-cell, CLL, ALL, mantle cell lymphoma, MM [27]
HMMR/Rhamn-TCRs CD8+ T cells CD8+ T cells AML [28]
  1. PBMC peripheral blood mononuclear cell