Table 1 Researches about leukemia-specific TCRs
From: T cell receptor-engineered T cells for leukemia immunotherapy
| Leukemia-specific TCRs | T cell type | HLA restriction | Leukemia | Research references |
|---|---|---|---|---|
| WT1-TCRs |
CD4+ T cells CD8+ T cells |
HLA-A2 HLA-DPB1*05:01 HLA-A*2402+ | AML, CML, MDS | [14,15,16,17,18,19] |
| FMNL1-TCRs | CD4+ T cells | HLA-DRB1*0101 HLADRB1*1101 | AML, lymphoma, myeloma | [20] |
| TERT-TCRs |
CD34+ cells PBMC CD8+ T cells |
HLA-A*0201 HLA-A*24:02 HLA-A2 | B-CLL, ATL, AML, B-ALL | [4, 21, 22] |
| AURKA-TCRs | CD8+ T cells | HLA-A*0201 | T-ALL, ATL | [23, 24] |
| MDM2-TCRs |
CD4+ T cells CD8+ T cells | HLA-A*0201 | AML, T lymphocytes | [25, 26] |
| BOB1-TCRs |
PBMC CD4+ T cells CD8+ T cells | HLA-B*07:02 | Lymphocytic B-cell, CLL, ALL, mantle cell lymphoma, MM | [27] |
| HMMR/Rhamn-TCRs | CD8+ T cells | CD8+ T cells | AML | [28] |